{"id":445,"date":"2020-02-25T21:24:26","date_gmt":"2020-02-25T21:24:26","guid":{"rendered":"https:\/\/cleanthehousatonic.com\/?page_id=445"},"modified":"2020-03-02T16:04:25","modified_gmt":"2020-03-02T16:04:25","slug":"health-effects","status":"publish","type":"page","link":"https:\/\/cleanthehousatonic.com\/?page_id=445","title":{"rendered":"HEALTH EFFECTS"},"content":{"rendered":"<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">In much the same way we had to push GE and the EPA and the Massachusetts agencies to fully recognize the extent of the PCB contamination, we had to pressure them to acknowledge the significant numbers of GE employees, and local residents who were suffering adverse health effects from their exposure to PCBs.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">We began first by listening to those who worked with PCBs, those who lived with them, the residents who had played in contaminated soil, those who watched their friends and neighbors die too soon.<\/span><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-184 aligncenter\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/LakewoodCancerMap.jpg?resize=625%2C417&#038;ssl=1\" alt=\"\" width=\"625\" height=\"417\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/LakewoodCancerMap.jpg?w=720&amp;ssl=1 720w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/LakewoodCancerMap.jpg?resize=300%2C200&amp;ssl=1 300w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/LakewoodCancerMap.jpg?resize=624%2C416&amp;ssl=1 624w\" sizes=\"auto, (max-width: 625px) 100vw, 625px\" \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>We asked Lakewood residents to stick a pin into a neighborhood map if they or any of their relatives had developed or died from cancer<\/strong><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Those who worked at GE breathed in the persistent fumes, stuck their arms up to their elbows in PCB oil, slogged through a foot of PCB oil on the floor. The men and women who worked with transformers and capacitors were never offered the option of changing out of their everyday clothes for more protective uniforms. And so they came home with oil-soaked clothes which went into the family washing machine with all the other clothes.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Lakewood residents shared with us the smell of heated PCB oil that hung over their neighborhood. Meanwhile Puff the Magic Dragon burned the PCB oil that was being pumped up from the underground plume\/lake that was located beneath their neighborhood. A GE worker told us that the incinerator burned so hot it had destroyed the sensor that was to register what was coming out of the stack. Depending on the weather and the wind, the smoke would linger atop the Newell Street neighborhood.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Those plumes ion PCB-contaminated oil infiltrated the basements of local businesses and homes. Deno Renieri, a retired GE worker, lived up the block from the plant on Newell Street, bordering the Housatonic. He took the sewer cover off to show Mickey Friedman the lake of oil that had migrated from Building 100 to the River.<\/span><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-446 aligncenter\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/DENOpointoil.jpg?resize=432%2C288&#038;ssl=1\" alt=\"\" width=\"432\" height=\"288\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/DENOpointoil.jpg?w=432&amp;ssl=1 432w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/DENOpointoil.jpg?resize=300%2C200&amp;ssl=1 300w\" sizes=\"auto, (max-width: 432px) 100vw, 432px\" \/><\/p>\n<p style=\"text-align: center;\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-447\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/DENOCUoil.jpg?resize=432%2C288&#038;ssl=1\" alt=\"\" width=\"432\" height=\"288\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/DENOCUoil.jpg?w=432&amp;ssl=1 432w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/DENOCUoil.jpg?resize=300%2C200&amp;ssl=1 300w\" sizes=\"auto, (max-width: 432px) 100vw, 432px\" \/><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Over the course of forty years we&#8217;ve watched as scientists better appreciated the damage PCBs and dioxins did and better understood that even the smallest dose of exposure was dangerous. Here are some facts to consider.\u00a0<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">According to the World Health Organization: &#8220;Dioxins and dioxin-like substances, including PCBs, are persistent organic pollutants (POPs) covered by the Stockholm Convention. They can travel long distances from the source of emission, and bioaccumulate in food chains.<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Human exposure to dioxins and dioxin-like substances has been associated with a range of toxic effects, including chloracne; reproductive, developmental and neurodevelopmental effects; immunotoxicity; and effects on thyroid hormones, liver and tooth development. They are also carcinogenic. Developmental effects in males are the most sensitive toxic end-point, making children \u2013 particularly breastfed infants \u2013 the population most at risk.&#8221;\u00a0<\/span><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-458 aligncenter\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/WHOPCBStrasnportedbyair.jpeg?resize=562%2C134&#038;ssl=1\" alt=\"\" width=\"562\" height=\"134\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/WHOPCBStrasnportedbyair.jpeg?w=432&amp;ssl=1 432w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/WHOPCBStrasnportedbyair.jpeg?resize=300%2C72&amp;ssl=1 300w\" sizes=\"auto, (max-width: 562px) 100vw, 562px\" \/><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a href=\"https:\/\/www.who.int\/ipcs\/assessment\/public_health\/dioxins\/en\/\">https:\/\/www.who.int\/ipcs\/assessment\/public_health\/dioxins\/en\/<\/a><\/span><\/p>\n<p style=\"text-align: center;\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-449\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/NoSafeLevelDCarpenter.jpeg?resize=432%2C265&#038;ssl=1\" alt=\"\" width=\"432\" height=\"265\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/NoSafeLevelDCarpenter.jpeg?w=432&amp;ssl=1 432w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/NoSafeLevelDCarpenter.jpeg?resize=300%2C184&amp;ssl=1 300w\" sizes=\"auto, (max-width: 432px) 100vw, 432px\" \/><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">The Center for Health, Environment &amp; Justice, in its\u00a0<\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">PCBs Factsheet offers some insight into the<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">health effects of PCBs, including concern about exposure in our schools: &#8220;<\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">The manufacture of polychlorinated biphenyls (PCBs) was stopped by the U.S. federal government in 1977 because of their harmful health effects and because PCBs are extremely persistent and last for decades in the environment. Unfortunately, PCBs remain in various forms in buildings created before 1979, such as PCB oils in school lighting ballast fixtures.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">People are exposed to PCBs by three routes, ingestion such as eating PCB-contaminated fish, skin or dermal absorption and inhalation when PCB\u2019s off-gas into the air. In schools, the most important route of exposure is inhalation as PCBs evaporate into the air. For instance, in New York City, some schools were found to have PCB concentrations in the air as high as 670,000 parts per million. Dr. David Carpenter, a national expert on PCBs, told the New York City Department of Education that \u201cthe health effects associated with exposure of children, teachers and school staff are serious and merit immediate removal of these sources of contamination.\u201d <\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Health Effects of PCBs<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">A growing number of studies have found serious health effects from exposure to PCBs.<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Cancer:<\/strong> PCBs are likely to cause cancer and are classified as a \u201cprobable carcinogen\u201d by the federal Environmental Protection Agency and the International Agency for Research on Cancer. In addition, a study found children\u2019s risk of developing acute lymphocytic leukemia, increased by two-fold when PCBs were detected in the dust of a room in which the child spent a significant amount of time.<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Immune System:<\/strong> PCBs suppress the immune system and thyroid function.<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Heart Disease:<\/strong> PCBs cause an elevated risk of cardiovascular disease, hypertension and diabetes. Hormonal Impacts: PCBs can alter the sex hormone systems, and have been found to lower the age at which a girl reaches puberty \u00a0and can reduce the levels of the male hormone, testosterone.<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Asthma:<\/strong> PCBs cause an overall increased risk of asthma and other infectious respiratory diseases. More specifically, children have an increased risk of asthma and other infectious respiratory diseases when exposed to persistent organic pollutants, including PCBs.<\/span><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-469 aligncenter\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/JacobsonFindings.jpeg?resize=530%2C397&#038;ssl=1\" alt=\"\" width=\"530\" height=\"397\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/JacobsonFindings.jpeg?w=432&amp;ssl=1 432w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/JacobsonFindings.jpeg?resize=300%2C225&amp;ssl=1 300w\" sizes=\"auto, (max-width: 530px) 100vw, 530px\" \/><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Birth Weight &amp; Infant Motor Skills:<\/strong> Women who are exposed to PCBs have babies that weigh slightly less\u00a0than babies from women who have not been exposed. In addition, children born to women who ate PCB- contaminated foods have abnormal responses in tests of infant behavior, including problems with motor skills and a decrease in short-term memory.<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Ability to Learn:<\/strong> PCBs are associated with cognitive problems and a reduction in the ability to learn and remember. For example, children who are exposed to PCBs before birth through maternal consumption of PCB contaminated fish were found to have a 6.2-point IQ deficit as compared to non-exposed children. Other studies have reported reduced alertness and increased tiredness in association with PCBs.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">\u00a0<a href=\"http:\/\/chej.org\/wp-content\/uploads\/Health-Effects-of-PCBs-Fact-Sheet.pdf\">http:\/\/chej.org\/wp-content\/uploads\/Health-Effects-of-PCBs-Fact-Sheet.pdf<\/a><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Health Effects of Environmental Endocrine Disrupters<\/strong><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><i>The greater an individual&#8217;s exposure to Endocrine Disrupting Chemicals (EDCs), the greater the risk of chronic disease, with the most concern for children, pregnant women, and anyone with a compromised immune system.<\/i><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">By Amy Hess-Fischl MS, RD, LDN, BC-ADM, CDE and Jodi Godfrey, MS, RD With Vincenzo Marotta, MD<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Endocrine disrupting chemicals (EDCs) are environmental chemicals that mimic, block, or interfere with hormones in the body. Increasing exposure to\u00a0 EDCs over the past 20 years appear responsible for the growing number of people with infertility, diabetes, early onset of puberty in girls and early menopause in women, cancer, birth defects, and neurobehavioral disorders, according to a statement issued by the Endocrine Society and IPEN, a global network of more than 500 public interest NGOs in more than 100 countries around the world.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">These environmental toxins have been found in our air, water, and soil as well as in a range of household products, including children\u2019s toys, furniture, and beauty products.\u00a0<\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">While it is not clear exactly how many EDCs exist, the most common EDCs include:<\/span><\/p>\n<ul>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Bisphenol A (BPA) used in certain children\u2019s toys, plastic bottles, and food containers, food can linings, and cash register receipts<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Dichlorodiphenyltrichloroethane (DDT, which is now banned) and other pesticides<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Flame retardants used in certain furniture and floor coverings<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Polychlorinated biphenyls (PCBs), which were used in electronics and building materials before being banned at the end of the 1970s<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Phthalates in beauty products and plastics<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Triclosan used in antibacterial products<\/span><\/li>\n<\/ul>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Known EDCs such as PCBs, BPA, and phthalates are found in blood, fat, and umbilical cord blood samples taken from people around the world. While some EDCs (eg, DDT and PCBs) have been banned, these chemicals may remain in the environment and food supply for decades. Some EDCs may be stored in fat cells for years after exposure and may be passed on to children during pregnancy or when breastfeeding.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">In contrast, BPA does not accumulate in the body, and studies have shown that minimizing the use of canned foods and plastic containers can reduce BPA levels found in the body. However, BPA is still used in so many products that the U.S. Centers for Disease Control and Prevention has estimated that more than 96% of Americans have BPA in their bodies.2<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><b>The Impact of EDCs on Hormones, and Health<\/b><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Endocrine disrupting chemicals may bind to an endocrine hormone\u2019s receptor, activating the hormone\u2019s production and triggering physiological processes. Conversely, some EDCs block endocrine hormones by binding to their receptors and blocking normal activation even in the presence of the natural hormones.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">The concern has grown since even a low level of exposure to EDCs can affect body functions, particularly in the most vulnerable populations including infants and children, pregnant women, and those who are immune compromised or frail.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><b>Of particular note, recent studies have shown the following<\/b>:<\/span><\/p>\n<ul>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Exposure to pesticides like DDT can increase the risk for cardiovascular disease and inflammation in women who are premenopausal.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Exposure to BPA has been linked to an increased risk of infertility, cancer, and metabolic disorders, including diabetes.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Exposure to BPA during pregnancy may increase offspring\u2019s risk for developing diabetes or cardiovascular disease later in life.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Early onset of menopause has been linked to 15 chemicals, including phthalates and PCBs.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">PCBs can interfere with thyroid hormone action in pregnant women, which may affect brain development in fetuses.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Men, women, and children exposed to high levels of phthalates may have reduced levels of testosterone.<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Exposure to EDCs has been estimated to cost between 150-260 billion euros per year in the European Union due to contributing to a number of diseases and health conditions.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><b>Two Endocrine Disrupters Linked to Thyroid Cancer<\/b><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">A red flag has just been raised about the potential for harm from exposure to two\u00a0common pollutants: bisphenol AF (BPA) and phytates (diethylhexylphthalate). In a study published in <i>Chemosphere<\/i>, the authors evaluated the blood levels of more than 14 EDCs and found a significant link between these two endocrine disrupters and thyroid cancer.12\u00a0<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">The researchers identified 55 patients from five different medical sites across Italy who were seeking treatment for thyroid nodules; their blood was evaluated for levels of these EDCs.12\u00a0\u00a0What they found was in patients with high levels of both BPA and phthalates\u00a0in their blood, there was a dose-response effect regarding the development differentiated thyroid cancer.\u00a0 No effect was found with the patient&#8217;s level of thyroid stimulating hormone (TSH).<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">In fact, the risk of developing thyroid cancer appears 14-fold higher in the individuals who have been exposed to low doses of these environmental toxins, according to Dr. Vincenzo Marotta, the lead study author, who is an oncologist from\u00a0 IRCCS\u00a0National Cancer Institute in Naples, Italy.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a href=\"https:\/\/www.endocrineweb.com\/professional\/other-endocrine-disorders\/health-effects-environmental-endocrine-disrupters\">https:\/\/www.endocrineweb.com\/professional\/other-endocrine-disorders\/health-effects-environmental-endocrine-disrupters<\/a><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">From the Department of Pediatrics, Emory University School of Medicine<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a href=\"https:\/\/www.pediatrics.emory.edu\/centers\/pehsu\/concern\/pcb.html#howcan\">https:\/\/www.pediatrics.emory.edu\/centers\/pehsu\/concern\/pcb.html#howcan<\/a><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">How can my child or I be exposed to PCBs?<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Because of their tendency to persist in the environment, small amounts of PCBs are present in almost all outside air, inside air, water, soil, and plants. Possible sources of exposure include:<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">An important route of environmental PCB exposure is through the diet, especially milk (breast and dairy), fish, and other meats.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">One reason for this is that PCBs tend to be stored in fatty materials such as meat. Since breast milk contains fat, nursing infants may be exposed to relatively high PCB levels from breast milk.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Another reason is that PCBs tend to accumulate in the body. Fish caught from PCB- contaminated waters tend to have higher levels of PCBs than the smaller fish or plant material they eat. When a pregnant mother eats these fish, these PCBs are once again poorly eliminated from the body. This phenomenon is called bioconcentration.<\/span><\/p>\n<p><strong><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Air<\/span><\/strong><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Increased exposure to PCBs may occur through breathing indoor air in buildings that have electrical appliances that use PCBs.\u00a0<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">PCBs may be found in old fluorescent lighting fixtures and old appliances such as television sets and refrigerators. When they get hot during use, these products may leak small amounts of PCBs into the air.\u00a0<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Also, higher levels of exposure can occur in outdoor air close to certain hazardous waste facilities.\u00a0<\/span><\/p>\n<p><strong><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Water<\/span><\/strong><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Exposure to PCBs can occur through various sources of contaminated water including wells, surface water, swimming areas, etc.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Since PCBs cannot dissolve well in water, these sources of exposure are not considered nearly as important as the diet.\u00a0<\/span><\/p>\n<p><strong><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Soil<\/span><\/strong><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">As mentioned, very small amounts of PCBs are found in almost all soils.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Over the years HRI was fortunate to invite some of America&#8217;s most respected experts on PCBs to come to Berkshire County. Other times we prevailed on EPA to bring their experts to talk to the community. Jim Cogliano of US EPA shared his expertise. Here is some of what he wrote about PCB exposure:<\/span><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-472 aligncenter\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/JimCoglianoAssessingCancerRisk1998.jpeg?resize=612%2C344&#038;ssl=1\" alt=\"\" width=\"612\" height=\"344\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/JimCoglianoAssessingCancerRisk1998.jpeg?w=612&amp;ssl=1 612w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/JimCoglianoAssessingCancerRisk1998.jpeg?resize=300%2C169&amp;ssl=1 300w\" sizes=\"auto, (max-width: 612px) 100vw, 612px\" \/><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Assessing the Cancer Risk from Environmental PCBs<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Vincent James Cogliano<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">US EPA National Center for Environmental Assessment 1998<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Download and read here:<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a href=\"https:\/\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/JimCogliano98PCBs.pdf\">JimCogliano98PCBs<\/a><\/span><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-484 aligncenter\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/ATSDRCaseStudyPCBs.jpeg?resize=432%2C577&#038;ssl=1\" alt=\"\" width=\"432\" height=\"577\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/ATSDRCaseStudyPCBs.jpeg?w=432&amp;ssl=1 432w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/ATSDRCaseStudyPCBs.jpeg?resize=225%2C300&amp;ssl=1 225w\" sizes=\"auto, (max-width: 432px) 100vw, 432px\" \/><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">In May 2018, the US ATSDR offered a course for medical professionals working in Environmental Medicine. It is one of the more succinct and useful presentations about the health dangers of PCBS. Here are some selections:<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;PCBs are chemicals formed by attaching one or more chlorine atoms (at the Xs in Figure 1 below) to a pair of connected benzene rings.<\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-479\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBSFigure1ATSDR.jpeg?resize=432%2C256&#038;ssl=1\" alt=\"\" width=\"432\" height=\"256\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBSFigure1ATSDR.jpeg?w=432&amp;ssl=1 432w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBSFigure1ATSDR.jpeg?resize=300%2C178&amp;ssl=1 300w\" sizes=\"auto, (max-width: 432px) 100vw, 432px\" \/><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;Depending on the number and position of chlorine atoms attached to the biphenyl ring structure, 209 different PCB congeners can be formed. PCB congeners can be divided into the coplanar, the mono-ortho-substituted PCBs, and other non-dioxin-like PCBs. The significance of this designation is that coplanar and some of the mono-ortho-substituted PCBs have dioxin-like toxicologic effects.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;The chlorination pattern of the PCBs determines the toxicity of the substance. A number of PCB congeners show <strong>dioxin-like <\/strong>toxicity. These PCBs have no more than one chlorine atom at the ortho-position (polychlorinated non-ortho and mono-ortho biphenyls). The phenyl rings of these molecules can rotate and adopt a coplanar structure, which leads to the same toxicity as the polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs). The toxic effects of these dioxin-like PCBs are discussed in detail in later sections of this document.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;A number of PCB congeners, however, have two or more of the ortho-positions in the biphenyl molecules occupied by chlorine molecules. For these, the two phenyl rings are not in the same plane, and these PCBs express <strong>non-dioxin-like <\/strong>toxicity.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;Commercial PCB products are mixtures of different PCB congeners and contain small amounts of PCDFs or PCDDs. Contamination is a concern because the toxicity of these contaminants is generally much greater than that of PCBs [ATSDR 2000].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;Because of their insulating and nonflammable properties, PCBs were marketed for nearly 50 years between 1929 and 1977. They were used in making<\/span><\/p>\n<ul>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Diffusion pump oils,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Extenders for pesticides,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Heat exchange and dielectric fluids in transformers and capacitors,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Hydraulic and lubricating fluids, and<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">As ingredients in caulking compounds, paints, adhesives, flame retardants, and plasticizers.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;In 1977, the United States banned production of PCBs because of their potential carcinogenicity.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;No known natural sources of PCBs exist. The United States banned production of these chemicals in 1977, when their ability to accumulate in the environment and to cause harmful effects became apparent [ATSDR 2000]. Today, the major source of exposure to ambient PCBs is environmental cycling of PCBs previously released into the environment.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;Between 1929 and 1977, more than 1.25 billion pounds of PCBs were produced in the United States [ATSDR 2000]. PCBs can be released into the general environment by or from<\/span><\/p>\n<ul>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Disposal of PCB-containing consumer products in municipal landfills<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Illegal or improper dumping of waste that contained PCBs, such as transformer fluids<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Leaks (fugitive emissions) from electrical transformers and capacitors containing PCBs<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Poorly maintained toxic waste sites <\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Once released into the environment, PCBs<\/span>\n<ul>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">bioaccumulate and biomagnify as they move up the food chain,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">degrade relatively slowly, and<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">are cycled and transported within the ecosystem<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">[ATSDR 2000; Safe 2007].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;PCBs have been identified in at least 500 of the 1,598 hazardous waste sites on the EPA\u2019s National Priorities List, and low levels of PCBs can be found throughout the world [ATSDR 2000].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;Once released into the environment, PCBs adsorb strongly to soil and sediment. As a result, these compounds tend to persist in the environment, with half-lives for most congeners ranging from months to years. PCBs leach from soil slowly, particularly the more highly chlorinated congeners, and translocate to plants via soil insignificantly.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;Cycling of PCBs through the environment involves volatilization from land and water surfaces into the atmosphere, with subsequent removal from the atmosphere by wet or dry deposition, then revolatilization. In the general population, inhalation of these airborne PCBs is one route of exposure, in addition to the food source of exposure to PCBs.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;The highest human exposures to polychlorinated biphenyls (PCBs) occur via the consumption of contaminated fish and, in certain occupational settings, via contact with equipment or materials made before 1977.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;Recent studies indicate that maternal consumption of PCB-contaminated fish can cause disturbances in reproductive parameters and neurobehavioral and developmental deficits in newborns and older children.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;Evidence shows that exposures to high concentrations of PCBs cause adverse dermal effects in humans. On the basis of sufficient evidence of carcinogenicity in humans and experimental animals, the International Agency for Research on Cancer (IARC) classified PCBs as carcinogenic to humans (Group 1) &#8230;.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;Older electrical transformers and capacitors can contain PCBs as a dielectric and heat-transfer fluid. Leaks in this equipment could allow PCBs to volatilize under conditions of increased temperature. A person with chronic exposure to the vapors or residue could eventually receive a significant PCB dose through both dermal and inhalation routes.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;Notably, potential carcinogenicity is the main reason PCB production was banned in the United States. EPA has determined that PCBs are probable human carcinogens and has assigned them the cancer weight-of-evidence classification B2. DHHS concluded that PCBs are reasonably anticipated to be carcinogenic in humans, based on sufficient evidence of carcinogenicity in animals. In February 2013, 26 experts from 12 countries met at the International Agency for Research on Cancer (IARC), Lyon, France, to reassess the carcinogenicity of polychlorinated biphenyls (PCBs). On the basis of sufficient evidence of carcinogenicity in humans and experimental animals, the IARC classified PCBs as carcinogenic to humans (Group 1). The classification is based on consistent association between PCB exposure and increased risk of melanoma in humans.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;In addition to possible dermal and inhalation exposure, the patient might be exposed by consuming contaminated fish, a potential source of PCBs.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;Select laboratories have the capability to perform PCB analyses on human tissue. The lipophilic nature of PCBs causes them to accumulate in fat; consequently, analysis of adipose tissue obtained by biopsy has been advocated as a measure of long-term exposure. Serum PCB analysis, which is less invasive than fat biopsy, is readily available. Health risks are not consistent necessarily with PCB levels, but a serum measurement is useful for gauging the patient\u2019s exposure.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;A correlation between increasing levels of serum PCBs and dermatologic findings, including chloracne, has not been found consistently in human epidemiologic studies. However, statistically significant associations between dermatologic effects and plasma levels of higher chlorinated PCB congeners have been reported.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;PCB compounds generally can be found at the parts per trillion (ppt) levels in the lipid stores of humans, especially persons living in an industrialized society. The general population is exposed to PCB compounds primarily through the ingestion of high-fat foods such as dairy products, eggs, animal fats, and some fish and wildlife [CDC 2009b; Hopf et al. 2009; Patterson et al. 2008]. By comparison, the case study patient\u2019s PCB serum level of 125 ppb is consistent with PCB exposure as a cause for his unusual acne, and PCB exposure might be contributing to the hepatic effects noted.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;The first objective should be to stop the exposure. In this case, the patient should stay away from the basement until the transformer is repaired and the basement area is cleaned by a professional familiar with PCB removal. He should also check with his state advisory on PCB-fish contamination and not eat fish from contaminated areas until his PCB level normalizes and the fish are declared uncontaminated. Many states issue advisories on fish consumption based on where the fish are caught. Fish advisories also provide guidance on how to choose fish that are safer to eat and on safer ways to prepare and cook fish. Avoiding exposure is especially important because no specific treatment exists for PCB accumulation. The need to avoid other hepatotoxic substances, including ethanol, should be stressed. Confirmation of exposure with a serum PCB level should be obtained.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ATSDR points to several areas of special concern:<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><b>&#8220;Children of mothers who eat large quantities of contaminated fish may be exposed to PCBs prenatally and while breastfeeding. <\/b><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;Several studies have reported that prenatal exposure to PCBs has been confirmed among children of consumers of contaminated fish and certain other groups [Fein et al. 1984; Jacobson JL et al. 1990b; Jacobson SW et al. 1985; Swain and Swain 1991]. Other studies have indicated that lactating women whose diets are high in PCB-contaminated fish potentially can increase the PCB exposure for their breastfeeding infants [Dewailly et al. 1989; Fitzgerald et al. 1998; Greizerstein et al. 1999; Rogan et al. 1985]. Fetuses and neonates are more sensitive to PCBs than are adults. During these early life stages, the hepatic microsomal enzyme systems that facilitate the metabolism and excretion of PCBs are not fully functional.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><b>&#8220;Farmers and their families who consume PCB-contaminated food via their own farm-raised beef and dairy cattle may be exposed. <\/b><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;During the 1940s and 1950s, the insides of concrete silos on many farms in the Midwest United States were coated with sealants containing PCBs. Over time, these sealants peeled off and became mixed with silage used to feed beef and dairy cattle. Farmers and their families who lived on these farms and who regularly ate farm- raised beef and dairy products were exposed to PCBs. Although most of these silos have been dismantled and removed, the remaining silos represent a potential source of exposure to PCBs [Hansen 1987; Humphrey 1983; Schantz et al. 1994].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><b>&#8220;Persons living near incinerators, other PCB- disposal facilities, or NPL hazardous waste sites where PCBs have been detected may be exposed. <\/b><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Persons living near incinerators, other PCB-disposal facilities, or any of the 500 current or former hazardous waste sites on the NPL sites where PCBs have been found may be also at increased risk for exposure to PCBs [ATSDR 1987; Hazdat 2000; Hermanson and Hites 1989; Robertson and Ludewig 2011; Stehr-Green et al. 1988; Wester et al. 1993].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><b>&#8220;Persons with Impaired Hepatic Function <\/b><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;PCBs are metabolized mainly in the liver, thus, persons with impaired hepatic function might be at increased risk because their ability to detoxify and excrete these compounds is diminished.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;Persons with incompletely developed glucuronide conjugation mechanisms (such as Gilbert syndrome or Crigler-Najjar syndrome) have impaired liver function, as do persons with chronic liver diseases such as cirrhosis or hepatitis B [Calabrese et al. 1977; Lester et al. 1964].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;Similarly, because hepatic function normally declines with age, elderly persons may be more susceptible to the effects of exposure to PCBs.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><b>&#8220;Children\u2019s Susceptibility <\/b><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;Infants and young children consume a greater amount of food per kilogram of body weight than do adults. Therefore, they have proportionately greater exposure to PCBs than do adults eating food with the same level of contamination [ATSDR 2000]. In addition, as mentioned earlier, fetuses and neonates are potentially more sensitive to PCBs than are adults because their hepatic microsomal enzyme systems that facilitate the metabolism and excretion of PCBs are not fully functional &#8230;\u00a0<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>&#8220;Absorption and Distribution <\/strong><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">&#8220;Humans can absorb PCBs by the Inhalation,<\/span>\u00a0<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Oral, and Dermal routes of exposure.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Although PCBs are readily absorbed into the body, they are slowly metabolized and excreted.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">PCBs initially distribute preferentially to the liver and muscle tissue.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">PCBs, especially the highly chlorinated congeners, tend to accumulate in lipid-rich tissues due to their lipophilic nature. Greater relative amounts of PCBs are usually found in<\/span><\/p>\n<ul>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Adipose tissue,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Breast milk,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">The liver, and\u00a0<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Skin [ATSDR 2000; Matthews et al. 1984] &#8230; \u00a0 \u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Environmental Alteration of PCB Mixtures <\/strong><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Environmental PCBs occur as mixtures whose compositions differ from the commercial mixtures. This is because after release into the environment, PCB mixture composition changes over time through chemical transformation and preferential bioaccumulation [Cogliano 1998].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Chemical transformation can occur through biodegradation of PCB mixtures in the environment. PCBs with higher chlorine content are extremely resistant to oxidation and hydrolysis.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Preferential bioaccumulation occurs in living organisms. Bioaccumulation through the food chain tends to concentrate congeners of higher chlorine content. In humans, bioaccumulated PCBs also appear to be more persistent in the body [Hovinga et al. 1992]. This is significant because bioaccumulated PCBs appear to be more toxic than original Aroclors in animals [Aulerich et al. 1986; Cogliano 1998].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>What Are Adverse Health Effects of PCB Exposure? <\/strong><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Human exposures to relatively high levels of PCBs have occurred primarily in persons working in plants that extensively manufactured and used PCBs and PCB- containing equipment. Occupational exposure to PCBs can result in a broad spectrum of effects that includes<\/span><\/p>\n<ul>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Increased levels of some liver enzymes, with possible hepatic damage,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Chloracne and related dermal lesions, and<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Respiratory problems [Alvares et al. 1977; Chase et al. 1982; Emmett and Emmett 1985; Lawton et al. 1985; Meigs 1954; Ouw et al. 1976; Safe S 1993; Warshaw et al. 1979].<\/span><\/li>\n<\/ul>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Potential adverse human health effects of low-level environmental exposure to PCBs are complex and still need further validation [Safe SH 2007].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">In animal studies, commercial PCBs elicit a broad range of toxic responses including:<\/span><\/p>\n<ul>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Acute lethality,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Body weight loss,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Carcinogenesis,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Dermal toxicity,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Fatty liver,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Genotoxicity,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Hepatomegaly,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Immunosuppressive effects,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Neurotoxicity,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Porphyria,<\/span>\u00a0<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Reproductive and developmental toxicity,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Thymic atrophy, and<\/span>\u00a0<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Thyroid hormone-level alterations.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Carcinogenic Effects<\/strong><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Epidemiologic studies have raised concerns about the potential carcinogenicity of PCBs.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">A retrospective analysis of a study of two plants that manufactured electrical capacitors in the United States found a significant increase in the incidence of cancer. The primary target tissues for the cancers were the liver, gallbladder, and biliary tract [Brown 1987].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Likewise, an increased incidence of melanomas associated with exposure to PCBs has also been observed for workers who manufactured capacitors [Bahn et al. 1976; Ruder et al. 2006; Sinks et al. 1992]. Sinks et al. [1992] observed the increased risks for brain cancer among workers exposed to PCBs in an electrical capacitor manufacturing plant in Indiana, and this finding has been further confirmed by a recent study from Ruder et al. [2006].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">One study suggests that exposure to electrical insulating fluids, for which the main constituent is PCBs, may cause malignant melanoma of the skin [Loomis et al. 1997].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">The results of a mortality study of workers employed between 1944 and 1977 at an electrical capacitor manufacturing plant were recently reported. The report pointed out that PCBs alone or in combination with other chemicals could be associated with increased risks for<\/span><\/p>\n<ul>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Liver or biliary,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Stomach, intestinal, and<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Thyroid cancers [Mallin et al. 2004].<\/span><\/li>\n<\/ul>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">A recent analysis of a cohort of 24,865 capacitor- manufacturing workers exposed to PCBs at three plants showed evidence of associations between cumulative exposure to PCBs and increased total cancer and intestinal cancer mortality among female long-term workers and excess myeloma for male long-term workers [Ruder et al. 2014].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">In contrast, increased cancer incidence was not observed in male workers who manufactured capacitors in Sweden exposed to PCBs for an average of 6.5 years [Gustavsson et al. 1986]. The results from the Swedish study, however, cannot rule out the possibility of a carcinogenic risk from PCB exposure because of the small size of the cohort and relatively brief follow-up period.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Different mixtures of PCBs had different potencies and, thus, different toxicity. As noted previously, PCB mixtures found in the environment are different from commercial PCB mixtures. EPA agreed that some mixtures of PCBs are more likely to cause cancer than others, and found that all PCBs mixtures can cause cancer [Cogliano 1998; EPA 1996c].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">In environmental case-control studies that compared PCB concentrations in breast tissue in both women with (case patients) and without (case controls) breast cancer, some studies reported higher levels of total PCBs among case patients than control patients [Falck et al. 1992; Guttes et al. 1998; Wassermann et al. 1976]. Other studies found no elevated PCB levels in breast tissue in patients with breast cancer [Aronson et al. 2000; Liljegren et al. 1998; Unger et al. 1984]. A recent occupational cohort study found no overall elevation in breast cancer risk after occupational exposure to PCBs [Silver et al. 2009].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">In persons without known occupational exposure to PCBs, elevations of PCB level in the adipose tissue and serum have been associated with an increased risk of non-Hodgkin lymphoma (NHL) [De Roos et al. 2005; Engel et al. 2007; Hardell E et al. 2001; Hardell L et al. 1996; Rothman et al. 1997].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">After registering as Yusho victims, 887 male and 874 female patients were observed for an average 11 years. A retrospective study found statistically significant increased liver cancer mortality rates among the males compared to national liver cancer mortality rates [Kuratsune et al. 1987].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">A retrospective mortality study of 1940 Yu-Cheng cases found no statistically significant increased mortality from liver and intrahepatic bile duct cancers [Hsieh et al. 1996].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Before the comprehensive study conducted by Mayes et al. [1998], only commercial mixtures 60% chlorinated had been tested, and controversy existed about whether mixtures with lower chlorine content were carcinogenic. The Mayes et al. study [Mayes et al. 1998] supported the position that all PCB mixtures can cause cancer. Data from animal studies have shown that PCBs cause gastrointestinal tract tumors, hepatocarcinomas, leukemia, lymphomas, and pituitary tumors [ATSDR 2000].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">On the basis of these laboratory data, EPA has determined that PCBs are probable human carcinogens and has assigned them the cancer weight-of-evidence classification B2 [IRIS 2012]. DHHS concluded that PCBs are reasonably anticipated to be carcinogenic in humans based on sufficient evidence of carcinogenicity in animals [NTP 2011].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">In February 2013, 26 experts from 12 countries met at the International Agency for Research on Cancer (IARC), Lyon, France, to reassess the carcinogenicity of PCBs. The Working Group considered more than 70 independent epidemiological studies with informative data for carcinogenicity of PCBs in human beings. On the basis of sufficient evidence of carcinogenicity in humans and experimental animals, the IARC classified PCBs as carcinogenic to humans (Group 1). The classification is based on consistent association between exposure to PCBs and increased risk of melanoma in humans [IARC 2013].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Other Effects <\/strong><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Occupational and epidemiologic studies have suggested or demonstrated other adverse health effects from exposure to PCBs. These health effects can involve the:<\/span><\/p>\n<ul>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Cardiovascular,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Gastrointestinal,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Immune,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Musculoskeletal, and<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Neurological systems.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">In southwest Quebec, adults who ate fish from PCB- contaminated waters had<\/span><\/p>\n<ul>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Significantly greater motor retardation,<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Poorer results on certain memory and attention tests, and<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Higher scores on a standardized confusion scale than did control adults.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">These neurological deficits were directly related to the frequency of fish consumption [Mergler et al. 1998].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Immune system effects reported in PCB-exposed populations include alterations in the ratio of helper to killer (CD4+\/CD8+) T-cells, decreases in IgA and IgM antibody levels, decreases in monocyte and granulocyte counts, and decreases in natural killer cell count [Svensson et al. 1994].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">In the Yusho and Yu-Cheng populations, the immunosuppressive effects of PCB exposure were associated with an increased incidence of persistent respiratory infection and enhanced responsiveness to mitogens [Guo et al. 1995].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Appetite loss has been reported in transformer and electrical equipment manufacturing workers exposed to various PCB-containing mixtures. Other nonspecific gastrointestinal symptoms experienced by workers exposed to PCBs include nausea, epigastric distress and pain, and intolerance to fatty foods [Emmett et al. 1988; Smith et al. 1982].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">A recent study has indicated that several PCB metabolites induce gene mutations, chromosome breaks, chromosome loss and polyploidization in cells in culture and even provided the first evidence that a PCB congener is mutagenic in vivo [Robertson and Ludewig 2011].<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">For those of you who want to do further research, here&#8217;s a list of the sources ATSDR relied on:<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><b>References <\/b>AAP. 2003. Polychlorinated Biphenyls, Dibenzofurans, and Dibenzodioxins. Handbook of Pediatric Environmental Health (21):215-22.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Alaspaa AO, Kuisma MJ, Hoppu K, et al. Out-of-hospital administration of activated charcoal by emergency medical services. Annals of Emergency Medicine 45(2):207-12 [updated 2005 February 2; accessed 2014 February 01]. Available from: http:\/\/www.sciencedirect.com\/science\/article\/pii\/S01960644 04012077<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Allen JR. 1975. Response of the nonhuman primate to polychlorinated biphenyl exposure. Federation Proceedings 34(8):1675-9.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Alvares AP, Fischbein A, Anderson KE, et al. 1977. Alterations in drug metabolism in workers exposed to polychlorinated biphenyls. Clinical Pharmacology &amp; Therapeutics 22(2):140-6.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Anderson HA, Falk C, Hanrahan L, et al. 1998. Profiles of Great Lakes critical pollutants: a sentinel analysis of human blood and urine. The Great Lakes Consortium. Environmental Health Perspectives 106(5):279-89.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Anonymous. 1997. Position paper of the American Council on Science and Health: public health concerns about environmental polychlorinated biphenyls (PCBs). Ecotoxicology &amp; Environmental Safety 38(2):71-84.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Arnold DL, Mes J, Bryce F, et al. 1990. A pilot study on the effects of Aroclor 1254 ingestion by rhesus and cynomolgus monkeys as a model for human ingestion of PCBs. Food &amp; Chemical Toxicology 28(12):847-57.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Aronson KJ, Miller AB, Woolcott CG, et al. 2000. Breast adipose tissue concentrations of polychlorinated biphenyls and other organochlorines and breast cancer risk. Cancer Epidemiology, Biomarkers &amp; Prevention 9(1):55-63.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ATSDR. 1987. Final Report: Exposure study of persons possibly exposed to polychlorinated biphenyl in Paoli, Pennsylvania. Atlanta, GA: U.S. Department of Health and HUman Services, Office of External Affairs, Exposure and Disease Registry Branch, Agency for Toxic Substances and Disease Registry.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ATSDR. 2000. Toxicological Profile for Polychlorinated Biphenyls (PCBs). US Department of Health and Human Services, Public Health Service Atalanta, GA.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">[ATSDR] Agency for Toxic Substances and Disease Registry. Addendum to the Toxicological Profile for Polychlorinated Biphenyls (PCBs). Atlanta GA [updated 2011 April; accessed 2014 February 01]. Available from: http:\/\/www.atsdr.cdc.gov\/toxprofiles\/pcbs_addendum.pdf .<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><span lang=\"DA\">Aulerich RJ, Ringer RK, Safronoff J, et al. 1986. <\/span>Assessment of primary vs. secondary toxicity of Aroclor 1254 to mink. Archives of Environmental Contamination &amp; Toxicology 15(4):393-9.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Bahn AK, Rosenwaike I, Hermann N, et al. 1976. Letter: Melanoma after exposure to PCB&#8217;s. New England Journal of Medicine 295(8):450.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Barsotti DA, Marlar RJ, Allen JR, et al. 1976. Reproductive dysfunction in rhesus monkeys exposed to low levels of polychlorinated biphenyls (Aoroclor 1248). Food &amp; Cosmetics Toxicology 14(2):99-103.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Brown DP. 1987. Mortality of workers exposed to polychlorinated biphenyls&#8211;an update. Archives of Environmental Health 42(6):333-9.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Calabrese EJ, Sorenson AJ, Calabrese EJ, et al. 1977. The health effects of PCBS with particular emphasis on human high risk groups. Reviews on Environmental Health 2(4):285-304.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Carpenter DO. 2008. Environmental contaminants as risk factors for developing diabetes. Reviews on Environmental Health 23(1):59-74.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">[CDC] Centers for Disease Control and Prevention. 2009a. Fourth National Report on Human Exposure to Environmental Chemicals. Atlanta GA [updated 2009a; accessed 2014 February 1]. Available from: http:\/\/www.cdc.gov\/exposurereport\/<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Chase KH, Wong O, Thomas D, et al. 1982. Clinical and metabolic abnormalities associated with occupational exposure to polychlorinated biphenyls (PCBs). Journal of Occupational Medicine 24(2):109-14.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Chyka PA, Seger D, Krenzelok EP, et al. Position paper: Single-dose activated charcoal. Clinical Toxicologists 43(2):61-87 [updated 2005; accessed 2014 February 01]. Available from: http:\/\/www.clintox.org\/documents\/positionpapers\/SingleDo seActivatedCharcoal.pdf<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Cogliano VJ. 1998. Assessing the cancer risk from environmental PCBs. Environmental Health Perspectives 106(6):317-23.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Colombi A, Maroni M, Ferioli Aea. 1982. Increase in urinary porphyrin excretion in workers exposed to polychlorinated biphenyls. <span lang=\"DA\">J Appl Toxicol (2):117-21. <\/span><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><span lang=\"DA\">Cooke PS, Zhao YD, Hansen LG, et al. 1996. <\/span>Neonatal polychlorinated biphenyl treatment increases adult testis size and sperm production in the rat. Toxicology &amp; Applied Pharmacology 136(1):112-7.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Crow KD. 1970. Chloracne. British Journal of Dermatology 83(5):599-600.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><span lang=\"NL\">De Roos AJ, Hartge P, Lubin JH, et al. 2005. <\/span>Persistent organochlorine chemicals in plasma and risk of non- Hodgkin&#8217;s lymphoma. Cancer Research 65(23):11214-26.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Dewailly E, Nantel A, Weber JP, et al. 1989. High levels of PCBs in breast milk of Inuit women from arctic Quebec. Bulletin of Environmental Contamination &amp; Toxicology 43(5):641-6.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Emmett EA and Emmett EA. 1985. Polychlorinated biphenyl exposure and effects in transformer repair workers. Environmental Health Perspectives 60:185-92.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Emmett EA, Maroni M, Jefferys J, et al. 1988. Studies of transformer repair workers exposed to PCBs: II. Results of clinical laboratory investigations. American Journal of Industrial Medicine 14(1):47-62.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Engel LS, Laden F, Andersen A, et al. 2007. Polychlorinated biphenyl levels in peripheral blood and non-Hodgkin&#8217;s lymphoma: a report from three cohorts. Cancer Research 67(11):5545-52.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">[EPA] U.S. Environmental Protection Agency. 1986b. Method 8080: Organochlorine pesticides and PCB. In: Test methods for evaluating solid waste SW-846. Washington, DC: U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, 8080-1 to 8080-27.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">[EPA] U.S. Environmental Protection Agency. 1992a. National Study of Chemical Residues in Fish. Washington, DC: U.S. Environmental Protection Agency. EPA Report No.: EPA 823-R-92-008a.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">[EPA] U.S. Environmental Protection Agency. 1992b. National Study of Chemical Residues in Fish. Washington, DC: US Environmental Protection Agency. EPA Report No.: EPA 823-R-92-008b.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">[EPA] U.S. Environmental Protection Agency. 1996c. PCBs: Cancer dose-response assessment and application to environmental mixtures. Washington, DC: US Environmental Protection Agency, National Center for Environmental Assessment, Office of Research and Development EPA\/600\/p-96\/001F.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">[EPA] U.S. Environmental Protection Agency Integrated Risk Information System [IRIS] Polychlorinated Biphenyls (PCBs). [updated 2012 August 09; accessed 2014 February 01]. Available from: http:\/\/www.epa.gov\/IRIS\/subst\/0294.htm<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Current drinking water standards. [EPA] U.S. Environmental Protection Agency. Washington DC [accessed 2014 February 01; updated 2012 March 06]. Available from: http:\/\/water.epa.gov\/lawsregs\/rulesregs\/sdwa\/curren tregulations.cfm<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Fait A, Grossman E, Self S, et al. 1989. Polychlorinated biphenyl congeners in adipose tissue lipid and serum of past and present transformer repair workers and a comparison group. Fundamental &amp; Applied Toxicology 12(1):42-55.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Falck F, Jr., Ricci A, Jr., Wolff MS, et al. 1992. Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer. Archives of Environmental Health 47(2):143-6.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">FDA. 1996c. Unavoidable contaminants in food for human consumption and food packaging material: Tolerances for polychlorinated biphenyls (PCBs). U.S. Food and Drug Administration 21 CFR 10930.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Fein GG, Jacobson JL, Jacobson SW, et al. 1984. Prenatal exposure to polychlorinated biphenyls: effects on birth size and gestational age. Journal of Pediatrics 105(2):315-20.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Fensterheim RJ. 1993. Documenting temporal trends of polychlorinated biphenyls in the environment. Regulatory Toxicology &amp; Pharmacology 18(2):181-201.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Fischbein A, Thornton J, Wolff MS, et al. 1982. Dermatological findings in capacitor manufacturing workers exposed to dielectric fluids containing polychlorinated biphenyls (PCBs). Archives of Environmental Health 37(2):69-74.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Fischbein A, Wolff MS, Lilis R, et al. 1979. Clinical findings among PCB-exposed capacitor manufacturing workers. 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New England Journal of Medicine 314(14):926-7.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Stehr-Green PA, Welty E, Burse VW, et al. 1988. Human exposure to polychlorinated biphenyls at toxic waste sites: investigations in the United States. Archives of Environmental Health 43(6):420-4.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Svensson BG, Hallberg T, Nilsson A, et al. 1994. Parameters of immunological competence in subjects with high\u00a0<\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">consumption of fish contaminated with persistent organochlorine compounds. International Archives of Occupational &amp; Environmental Health 65(6):351-8.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Swain WR and Swain WR. 1991. Effects of organochlorine chemicals on the reproductive outcome of humans who consumed contaminated Great Lakes fish: an epidemiologic consideration. Journal of Toxicology &amp; Environmental Health 33(4):587-639.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Unger M, Kiaer H, Blichert-Toft M, et al. 1984. Organochlorine compounds in human breast fat from deceased with and without breast cancer and in a biopsy material from newly diagnosed patients undergoing breast surgery. Environmental Research 34(1):24-8.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Warshaw R, Fischbein A, Thornton J, et al. 1979. Decrease in vital capacity in PCB-exposed workers in a capacitor manufacturing facility. Annals of the New York Academy of Sciences 320:277-83.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Wassermann M, Nogueira DP, Tomatis L, et al. 1976. Organochlorine compounds in neoplastic and adjacent apparently normal breast tissue. Bulletin of Environmental Contamination &amp; Toxicology 15(4):478-84.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Welsh MS. 1995. Extraction and gas chromatography\/electron capture analysis of polychlorinated biphenyls in railcar paint scrapings. Appl Occup Environ Hyg 10(3):175-81.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Wester RC, Bucks DA, Maibach HI, et al. 1983. Polychlorinated biphenyls (PCBs): dermal absorption, systemic elimination, and dermal wash efficiency. Journal of Toxicology &amp; Environmental Health 12(4-6):511-9.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Wester RC, Maibach HI, Sedik L, et al. 1993. Percutaneous absorption of PCBs from soil: in vivo rhesus monkey, in vitro human skin, and binding to powdered human stratum corneum. Journal of Toxicology &amp; Environmental Health 39(3):375-82.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">To download and read the\u00a0ATSDR Case Studies in Environmental Medicine &#8211;\u00a0Polychlorinated Biphenyls (PCBs) Toxicity<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a href=\"https:\/\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/ATSDRCaseStudy.pdf\">ATSDRCaseStudy<\/a><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">We recently came across a December 2019 review of a recent study by Boston University School of Public Health (BUSPH) that we think will be of great concern to those living near to the Housatonic River.\u00a0<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a href=\"https:\/\/www.news-medical.net\/news\/20191203\/Study-estimates-health-effects-of-breathing-airborne-PCBs-around-New-Bedford-Harbor.aspx\">https:\/\/www.news-medical.net\/news\/20191203\/Study-estimates-health-effects-of-breathing-airborne-PCBs-around-New-Bedford-Harbor.aspx<\/a><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Study estimates health effects of breathing airborne PCBs around New Bedford Harbor<\/strong><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Reviewed by\u00a0Kate Anderton, B.Sc. (Editor)<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">December 3, 2019<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">The levels of PCBs in the air are high enough to affect thyroid hormones in people who reside close to the harbor, raising the risk of diabetes, low birth weight, and impaired neurodevelopment.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">A new Boston University School of Public Health (BUSPH) study indicates that the contaminated water of New Bedford Harbor may pose an airborne health hazard for residents living nearby in Acushnet, Dartmouth, Fairhaven, and New Bedford. The U.S. Environmental Protection Agency (EPA) declared the southeastern Massachusetts harbor a Superfund site and has been cleaning up sediment contaminated with polychlorinated biphenyls (PCBs) since the 1990s, focusing efforts on PCB levels in the sediment and in fish consumed from the harbor, and associated cancer risks.<\/span><\/p>\n<p style=\"text-align: center;\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-499\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/NewBedfordAirbornePCBs.jpeg?resize=432%2C254&#038;ssl=1\" alt=\"\" width=\"432\" height=\"254\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/NewBedfordAirbornePCBs.jpeg?w=432&amp;ssl=1 432w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/NewBedfordAirbornePCBs.jpeg?resize=300%2C176&amp;ssl=1 300w\" sizes=\"auto, (max-width: 432px) 100vw, 432px\" \/><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">But the new study, published in\u00a0<em>Science of the Total Environment<\/em>, is the first to estimate the non-cancer health effects of breathing airborne PCBs around the harbor, namely thyroid hormone effects.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><em>Residents have been concerned about the air for over a decade. Our study shows that they are correct to be concerned. It also indicates that it&#8217;s important to monitor the PCBs in air as a measure of a successful cleanup.<\/em><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><em>Dr. Wendy Heiger-Bernays, the study&#8217;s corresponding author and a clinical professor of environmental health at BUSPH<\/em><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">By request from community members, the researchers previously measured airborne PCB levels in various locations around the harbor in 2015 and 2016, including during a period of hydraulic dredging as part of the site&#8217;s cleanup. For the new study, the researchers estimated the health effects of these measurements. The EPA has no published guidelines for the amount of PCBs in air that might be safe to breathe, so the BUSPH team used evidence from other researchers&#8217; rodent studies to develop a human-equivalent estimate of the likelihood of different levels of airborne PCB exposure to cause &#8220;unreasonable risk&#8221; as the EPA defines it. They found that the airborne PCB levels were high enough to potentially affect the thyroid hormones of residents, particularly those living within 625 meters (0.4 miles) of the harbor.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><em>In addition to cancers, residents have been very concerned about other health problems that are not typically considered by health agencies when regulating exposures. Although clean-up of the harbor is nearly complete, and some may feel this is &#8216;too little too late,&#8217; we hope our results can inform other settings where inhaled PCBs are a risk, so that subtler human health risks are factored into the equation.<\/em><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><em>Dr. Madeleine Scammell, associate professor of environmental health at BUSPH and co-lead of the study<\/em><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">To download and read the article:<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a href=\"https:\/\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/AirbornePCBSNewBedford.pdf\">AirbornePCBSNewBedford<\/a><\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">You might also be interested in the work Senator Market (D-MA) has done on the continuing threat PCBs pose to our schoolchildren:<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\"><a href=\"https:\/\/www.ewg.org\/research\/report-highlights-widespread-pcb-contamination-schools\">https:\/\/www.ewg.org\/research\/report-highlights-widespread-pcb-contamination-schools<\/a><\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\"><em>WEDNESDAY, OCTOBER 5, 2016<\/em><\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\"><strong>By Olga V. Naidenko, Ph.D, Senior Science Advisor for Children&#8217;s Environmental Health, and Melanie Benesh, J.D., Legislative Attorney<\/strong><\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\"><strong>DANGEROUS MONSANTO CHEMICAL REMAINS IN THOUSANDS OF SCHOOLS<\/strong><\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">As many as 26,000 U.S. schools serving up to 14 million students may be contaminated with unsafe concentrations of toxic polychlorinated biphenyls (PCBs) leaching from caulks, sealants, and other aging building materials and fixtures, according to a recent study by scientists at the Harvard T.H. Chan School of Public Health.<a href=\"https:\/\/www.ewg.org\/research\/report-highlights-widespread-pcb-contamination-schools#ref1\"><strong>[1]<\/strong><\/a><\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">Sen. Edward Markey, D-Mass., analyzing the Harvard findings, has calculated that up to 30 percent of American children in elementary, middle and high school may still be exposed to these dangerous industrial chemicals, despite a 1976 ban by Congress. PCBs were the only family of chemicals for which such action has been taken. \u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">PCBs, manufactured from the 1920s to the 1970s by Monsanto, were once used as insulators for electrical equipment, oils for hydraulic systems and motors, plasticizers in paints and caulks, components of fluorescent light fixtures, and ingredients in consumer products such as carbonless copy paper. \u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">The World Health Organization categorizes PCBs as carcinogens. These chemicals can also cause a variety of health problems, harm to the immune system, neurological damage, learning deficits, lowered birth weight and decreased thyroid hormone function.\u00a0<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">School children are most often exposed to these chemicals by old, PCB-laden caulk and outdated fluorescent light ballasts. They may also come in contact with PCBs that migrated into paint, floor finishes or soil outside.\u00a0<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">According to data the Environmental Protection Agency provided to Markey\u2019s office, which was also analyzed by EWG, over the past 10 years the EPA has received 286 reports of potential PCB contamination in school buildings in 20 states. These incidents ranged from the removal of a single fluorescent light fixture to large-scale remediation undertaken by some of the nation\u2019s largest school districts. Moreover, an unknown but probably substantial number of students and teachers in numerous colleges and universities come into frequent contact with PCB-laden materials.<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">Dr. Robert Herrick, the primary author of the Harvard study, stated:<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">These data demonstrate that PCBs in schools are a national problem. And while the scope of the problem remains poorly characterized, it is clear that where people look for PCBs in schools, they are very likely to find them.\u00a0The presence of PCB contamination in our schools causes elevated blood PCB levels among both teachers and students.\u00a0The effect of these PCBs on the health of people in these buildings has never been studied, but given the evidence that PCBs cause cancer, and reproductive and developmental problems, it is essential that this source of PCB exposure be eliminated from our schools.<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">Not long after Monsanto started producing PCBs, the company discovered they were health hazards, but hid that information from the public and regulators. This began a decades-long cover-up, the likes of which is unmatched in the annals of corporate environmental malfeasance, and was not fully revealed until internal company documents were unearthed in lawsuits. In 2003, thousands of these documents were made public in\u00a0<a href=\"https:\/\/www.ewg.org\/research\/anniston-alabama\"><strong>EWG\u2019s Chemical Industry Archives,<\/strong><\/a>\u00a0which documented the shocking story of Monsanto\u2019s callous poisoning of Anniston, Ala.<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">The most urgent questions surround possible contamination in the tens of thousands of schools that may not have been tested for PCBs, but are at risk for having them. Any school building constructed between the 1950s and the late 1970s could test positive for these chemicals, potentially endangering the health of students and teachers. Schools built in this time frame should test for PCBs in caulk, dust and in the air. School systems with old fluorescent light fixtures should develop disposal and replacement plans.<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">Dr. David Carpenter, director of the Institute for Health and the Environment at the University of Albany and one of the nation\u2019s leading researchers of PCB impacts on human health, stated:<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">PCBs are known to cause a reduction in learning ability and IQ. The last thing you want in a school is to have children exposed to a neurotoxic chemical that will reduce their ability to learn. PCBs in materials like caulk or leaking fluorescent light ballasts slowly volatilize, and children and teachers will inhale these vapor-phase PCBs continuously while in a PCB-contaminated school.<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">Caulk made in the 1950s to 1970s commonly contained PCBs. The material can break down to release PCBs that can migrate into air and adjacent structural materials such as bricks, mortar, concrete and soil. Under EPA regulations, materials with more than 50 parts per million of PCBs must be removed or properly remediated. In recent tests at two schools in Malibu, Calif., caulk concentrations of PCBs up to 570,000 parts per million have been found, vastly exceeding the EPA limit.<a href=\"https:\/\/www.ewg.org\/research\/report-highlights-widespread-pcb-contamination-schools#ref2\"><strong>[2]<\/strong><\/a><\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">Earlier this month, in response to a citizen\u2019s suit filed by parents of school children against the Santa Monica-Malibu school district, a\u00a0<a href=\"http:\/\/smdp.com\/smmusd-lawsuit-ruling-malibu-pcb-removal-2019\/157092\"><strong>federal judge in Los Angeles ordered<\/strong><\/a>\u00a0all PCBs removed from two Malibu schools.<a href=\"https:\/\/www.ewg.org\/research\/report-highlights-widespread-pcb-contamination-schools#ref3\"><strong>[3]<\/strong><\/a><\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">However, the EPA does not require schools to test for the presence of PCBs. No national database exists that summarizes whether buildings were tested, levels of PCBs in caulk detected in various buildings that were tested, the remediation measures undertaken and whether these measures were effective. \u00a0<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">Even when school systems remove caulk and other PCB-laden materials, the chemicals may linger in other adjacent materials, such as wooden window frames, brick and stucco, which is why confirmation testing after PCB removal is essential. \u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">The EPA acknowledges that all fluorescent lights that contain PCBS currently in use have exceeded their designated life spans. It is unknown how many of these light fixtures have already been removed and how many remain in use. These lights are at a heightened risk of rupture, leaching and crumbling, increasing the chance of subsequent PCB exposure for people in the buildings. Cleanup costs after a rupture could be significant.\u00a0<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">The EPA recommends that any fluorescent light fixture that contains PCBs should be removed.<a href=\"https:\/\/www.ewg.org\/research\/report-highlights-widespread-pcb-contamination-schools#ref4\"><strong>[4]<\/strong><\/a>\u00a0But the agency does not require removal unless PCB-contaminated liquid is leaking out of the light fixture.<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">The EPA also recommends schools should remove caulk, paint and other building materials that contain PCBs \u00a0during renovations and repairs.<a href=\"https:\/\/www.ewg.org\/research\/report-highlights-widespread-pcb-contamination-schools#ref5\"><strong>[5]<\/strong><\/a>\u00a0While planning for long-term remediation, school administrators may consider mitigation measures such as covering a PCB-containing material with another material, a process known as encapsulation.<a href=\"https:\/\/www.ewg.org\/research\/report-highlights-widespread-pcb-contamination-schools#ref6\"><strong>[6]<\/strong><\/a>\u00a0However, scientists do not know whether covering PCB sources such as caulk, contaminated masonry, or wood, can effectively contain the spread of PCBs.<a href=\"https:\/\/www.ewg.org\/research\/report-highlights-widespread-pcb-contamination-schools#ref7\"><strong>[7]<\/strong><\/a>\u00a0According to Herrick, the Harvard scientist, \u201cThe verdict on PCB encapsulation is still out and school administrators should approach it very cautiously.\u201d<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">Children may be exposed to a wide range of environmental hazards in schools \u2013 not only PCBs but also asbestos, radon, mold, cleaner chemicals, pesticides, and lead in drinking water. Like PCBs, asbestos and radon are still found in schools across the nation.<a href=\"https:\/\/www.ewg.org\/research\/report-highlights-widespread-pcb-contamination-schools#ref8\"><strong>[8]<\/strong><\/a>\u00a0A 2012 report by CNN estimated that one-third of U.S. schools have mold, dust and other indoor air pollution problems.<a href=\"https:\/\/www.ewg.org\/research\/report-highlights-widespread-pcb-contamination-schools#ref9\"><strong>[9]<\/strong><\/a><\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">With the exception of asbestos, in most cases schools are not required to regularly monitor or remediate these environmental hazards, nor are they required to even notify parents that these hazards may exist. While this report focuses on the health risks of PCBs in schools, American school systems and the communities that support them need a substantial investment in school infrastructure to eliminate many types of environmental hazards.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">1\u00a0Robert F. Herrick et al. 2016. Review of PCBs in US Schools: A Brief History, an Estimate of the Number of Impacted Schools, and an Approach for Evaluating Indoor Air Samples. Environmental Science and Pollution Research, 23(3):1975-1985.<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">2\u00a0Complaint at 30, Am. Unites for Kids v. Lyon, 2016 U.S. Dist. LEXIS 118447 (C.D. Cal. Sept. 1, 2016) (No. CV 15-2124). See also, Susan Klosterhaus et al. 2014. Polychlorinated Biphenyls in the Exterior Caulk of San Francisco Bay Area Buildings, California, USA. Environment International, (66):38\u201343.<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">3\u00a0Am. Unites for Kids v. Lyon, No. CV 15-2124, 2016 U.S. Dist. LEXIS 118447 (C.D. Cal. Sept. 1, 2016).<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">4\u00a0U. S. Environmental Protection Agency. 2016. Polychlorinated Biphenyl (PCB)-Containing Fluorescent Light Ballasts (FLBs) in School Buildings. Available at:\u00a0<a href=\"https:\/\/www.epa.gov\/pcbs\/polychlorinated-biphenyl-pcb-containing-fluorescent-light-ballasts-flbs-school-buildings\"><strong>www.epa.gov\/pcbs\/polychlorinated-biphenyl-pcb-containing-fluorescent-light-ballasts-flbs-school-buildings<\/strong><\/a><\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">5\u00a0U. S. Environmental Protection Agency. 2015. Fact Sheet on Practical Actions for Reducing Exposure to Polychlorinated Biphenyls (PCBs) in Schools and Other Buildings. July 28, 2015. Available at:\u00a0<a href=\"https:\/\/www.epa.gov\/sites\/production\/files\/2016-03\/documents\/practical_actions_for_reducing_exposure_to_pcbs_in_schools_and_other_buildings.pdf\"><strong>www.epa.gov\/sites\/production\/files\/2016-03\/documents\/practical_actions_for_reducing_exposure_to_pcbs_in_schools_and_other_buildings.pdf<\/strong><\/a><\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">6\u00a0Kathleen W. Brown et al. 2016. PCB Remediation in Schools: A Review. Environmental Science and Pollution Research, 23:1986-1997.<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">7\u00a0U.S. Environmental Protection Agency. 2015. Laboratory Study of Polychlorinated Biphenyl (PCB) Contamination in Buildings: Evaluation of the Encapsulation Method. Available at:\u00a0<a href=\"https:\/\/www.epa.gov\/sites\/production\/files\/2015-08\/documents\/pcb_encapsulation_fs.pdf\"><strong>https:\/\/www.epa.gov\/sites\/production\/files\/2015-08\/documents\/pcb_encapsulation_fs.pdf<\/strong><\/a><\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">8\u00a0Report written by the staff of Senator Edward J. Markey using the responses from a survey sent by Senator Markey and Senator Barbara Boxer. Failing the Grade: Asbestos in America\u2019s Schools. December 2015. Available at\u00a0<a href=\"http:\/\/www.markey.senate.gov\/imo\/media\/doc\/2015-12-Markey-Asbestos-Report-Final.pdf\"><strong>www.markey.senate.gov\/imo\/media\/doc\/2015-12-Markey-Asbestos-Report-Final.pdf<\/strong><\/a>. See also, U. S. Environmental Protection Agency. 2016. Radon in Schools. Available at\u00a0<a href=\"https:\/\/www.epa.gov\/radon\/radon-schools\"><strong>www.epa.gov\/radon\/radon-schools<\/strong><\/a><\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">9\u00a0David S. Martin, Are Schools Making Kids Sick? CNN, Jan. 14, 2012. Available at www.cnn.com\/2012\/01\/14\/health\/school-indoor-air-pollution\/index.html<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Dr. David Carpenter, one of America&#8217;s most respected experts on PCBs, was generous enough to come multiple times to speak to Berkshire audiences:<\/span><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-504 aligncenter\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBExposureDCarpenter.jpeg?resize=565%2C429&#038;ssl=1\" alt=\"\" width=\"565\" height=\"429\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBExposureDCarpenter.jpeg?w=432&amp;ssl=1 432w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBExposureDCarpenter.jpeg?resize=300%2C228&amp;ssl=1 300w\" sizes=\"auto, (max-width: 565px) 100vw, 565px\" \/><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-506 aligncenter\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/DCarpenterAirTransport.jpeg?resize=625%2C436&#038;ssl=1\" alt=\"\" width=\"625\" height=\"436\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/DCarpenterAirTransport.jpeg?resize=1024%2C714&amp;ssl=1 1024w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/DCarpenterAirTransport.jpeg?resize=300%2C209&amp;ssl=1 300w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/DCarpenterAirTransport.jpeg?resize=768%2C536&amp;ssl=1 768w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/DCarpenterAirTransport.jpeg?resize=624%2C435&amp;ssl=1 624w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/DCarpenterAirTransport.jpeg?w=1062&amp;ssl=1 1062w\" sizes=\"auto, (max-width: 625px) 100vw, 625px\" \/><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\" wp-image-508 aligncenter\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/WhatLevelsSafe.jpeg?resize=625%2C452&#038;ssl=1\" alt=\"\" width=\"625\" height=\"452\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/WhatLevelsSafe.jpeg?w=432&amp;ssl=1 432w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/WhatLevelsSafe.jpeg?resize=300%2C217&amp;ssl=1 300w\" sizes=\"auto, (max-width: 625px) 100vw, 625px\" \/><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-510\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/HowLongPCBsBodies.jpeg?resize=625%2C422&#038;ssl=1\" alt=\"\" width=\"625\" height=\"422\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/HowLongPCBsBodies.jpeg?w=432&amp;ssl=1 432w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/HowLongPCBsBodies.jpeg?resize=300%2C203&amp;ssl=1 300w\" sizes=\"auto, (max-width: 625px) 100vw, 625px\" \/><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-513\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/DCDiseasesConcern.jpeg?resize=625%2C417&#038;ssl=1\" alt=\"\" width=\"625\" height=\"417\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/DCDiseasesConcern.jpeg?w=432&amp;ssl=1 432w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/DCDiseasesConcern.jpeg?resize=300%2C200&amp;ssl=1 300w\" sizes=\"auto, (max-width: 625px) 100vw, 625px\" \/><\/p>\n<p style=\"text-align: center;\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-515\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/AkwesasneMohawks.jpeg?resize=620%2C478&#038;ssl=1\" alt=\"\" width=\"620\" height=\"478\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/AkwesasneMohawks.jpeg?w=432&amp;ssl=1 432w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/AkwesasneMohawks.jpeg?resize=300%2C231&amp;ssl=1 300w\" sizes=\"auto, (max-width: 620px) 100vw, 620px\" \/><\/p>\n<p style=\"text-align: center;\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-517\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/1000Individuals.jpeg?resize=624%2C364&#038;ssl=1\" alt=\"\" width=\"624\" height=\"364\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/1000Individuals.jpeg?w=432&amp;ssl=1 432w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/1000Individuals.jpeg?resize=300%2C175&amp;ssl=1 300w\" sizes=\"auto, (max-width: 624px) 100vw, 624px\" \/><\/p>\n<p style=\"text-align: center;\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-519\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/FourIQTests.jpeg?resize=624%2C277&#038;ssl=1\" alt=\"\" width=\"624\" height=\"277\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/FourIQTests.jpeg?w=432&amp;ssl=1 432w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/FourIQTests.jpeg?resize=300%2C133&amp;ssl=1 300w\" sizes=\"auto, (max-width: 624px) 100vw, 624px\" \/><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-537\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/CognitiveVariables.jpeg?resize=625%2C470&#038;ssl=1\" alt=\"\" width=\"625\" height=\"470\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/CognitiveVariables.jpeg?w=834&amp;ssl=1 834w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/CognitiveVariables.jpeg?resize=300%2C226&amp;ssl=1 300w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/CognitiveVariables.jpeg?resize=768%2C577&amp;ssl=1 768w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/CognitiveVariables.jpeg?resize=624%2C469&amp;ssl=1 624w\" sizes=\"auto, (max-width: 625px) 100vw, 625px\" \/><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-538\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/Adults.jpeg?resize=625%2C327&#038;ssl=1\" alt=\"\" width=\"625\" height=\"327\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/Adults.jpeg?w=835&amp;ssl=1 835w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/Adults.jpeg?resize=300%2C157&amp;ssl=1 300w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/Adults.jpeg?resize=768%2C402&amp;ssl=1 768w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/Adults.jpeg?resize=624%2C327&amp;ssl=1 624w\" sizes=\"auto, (max-width: 625px) 100vw, 625px\" \/><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-540\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/ThyroidHormone.jpeg?resize=625%2C278&#038;ssl=1\" alt=\"\" width=\"625\" height=\"278\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/ThyroidHormone.jpeg?w=822&amp;ssl=1 822w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/ThyroidHormone.jpeg?resize=300%2C134&amp;ssl=1 300w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/ThyroidHormone.jpeg?resize=768%2C342&amp;ssl=1 768w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/ThyroidHormone.jpeg?resize=624%2C278&amp;ssl=1 624w\" sizes=\"auto, (max-width: 625px) 100vw, 625px\" \/><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"wp-image-543 aligncenter\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBsSexHormones.jpeg?resize=624%2C312&#038;ssl=1\" alt=\"\" width=\"624\" height=\"312\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBsSexHormones.jpeg?w=432&amp;ssl=1 432w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBsSexHormones.jpeg?resize=300%2C150&amp;ssl=1 300w\" sizes=\"auto, (max-width: 624px) 100vw, 624px\" \/><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-545\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBsHeartDisease.jpeg?resize=625%2C337&#038;ssl=1\" alt=\"\" width=\"625\" height=\"337\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBsHeartDisease.jpeg?w=432&amp;ssl=1 432w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBsHeartDisease.jpeg?resize=300%2C162&amp;ssl=1 300w\" sizes=\"auto, (max-width: 625px) 100vw, 625px\" \/><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-547\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBsDiabetes.jpeg?resize=625%2C251&#038;ssl=1\" alt=\"\" width=\"625\" height=\"251\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBsDiabetes.jpeg?w=847&amp;ssl=1 847w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBsDiabetes.jpeg?resize=300%2C120&amp;ssl=1 300w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBsDiabetes.jpeg?resize=768%2C308&amp;ssl=1 768w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBsDiabetes.jpeg?resize=624%2C250&amp;ssl=1 624w\" sizes=\"auto, (max-width: 625px) 100vw, 625px\" \/><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-549\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/AlaskanNatives.jpeg?resize=625%2C378&#038;ssl=1\" alt=\"\" width=\"625\" height=\"378\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/AlaskanNatives.jpeg?w=835&amp;ssl=1 835w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/AlaskanNatives.jpeg?resize=300%2C181&amp;ssl=1 300w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/AlaskanNatives.jpeg?resize=768%2C464&amp;ssl=1 768w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/AlaskanNatives.jpeg?resize=624%2C377&amp;ssl=1 624w\" sizes=\"auto, (max-width: 625px) 100vw, 625px\" \/><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-553\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBlevelHumanSerum.jpeg?resize=625%2C351&#038;ssl=1\" alt=\"\" width=\"625\" height=\"351\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBlevelHumanSerum.jpeg?w=432&amp;ssl=1 432w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBlevelHumanSerum.jpeg?resize=300%2C169&amp;ssl=1 300w\" sizes=\"auto, (max-width: 625px) 100vw, 625px\" \/><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-555\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/YupiksHigherLevels.jpeg?resize=625%2C324&#038;ssl=1\" alt=\"\" width=\"625\" height=\"324\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/YupiksHigherLevels.jpeg?w=792&amp;ssl=1 792w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/YupiksHigherLevels.jpeg?resize=300%2C156&amp;ssl=1 300w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/YupiksHigherLevels.jpeg?resize=768%2C399&amp;ssl=1 768w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/YupiksHigherLevels.jpeg?resize=624%2C324&amp;ssl=1 624w\" sizes=\"auto, (max-width: 625px) 100vw, 625px\" \/><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-557\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PolarBearSeal.jpeg?resize=625%2C469&#038;ssl=1\" alt=\"\" width=\"625\" height=\"469\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PolarBearSeal.jpeg?w=883&amp;ssl=1 883w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PolarBearSeal.jpeg?resize=300%2C225&amp;ssl=1 300w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PolarBearSeal.jpeg?resize=768%2C576&amp;ssl=1 768w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PolarBearSeal.jpeg?resize=624%2C468&amp;ssl=1 624w\" sizes=\"auto, (max-width: 625px) 100vw, 625px\" \/> <img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-558\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PolarBears.jpeg?resize=625%2C502&#038;ssl=1\" alt=\"\" width=\"625\" height=\"502\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PolarBears.jpeg?w=852&amp;ssl=1 852w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PolarBears.jpeg?resize=300%2C241&amp;ssl=1 300w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PolarBears.jpeg?resize=768%2C617&amp;ssl=1 768w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PolarBears.jpeg?resize=624%2C501&amp;ssl=1 624w\" sizes=\"auto, (max-width: 625px) 100vw, 625px\" \/><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-560\" src=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBConclusions.jpeg?resize=625%2C342&#038;ssl=1\" alt=\"\" width=\"625\" height=\"342\" srcset=\"https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBConclusions.jpeg?w=788&amp;ssl=1 788w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBConclusions.jpeg?resize=300%2C164&amp;ssl=1 300w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBConclusions.jpeg?resize=768%2C420&amp;ssl=1 768w, https:\/\/i0.wp.com\/cleanthehousatonic.com\/wp-content\/uploads\/2020\/02\/PCBConclusions.jpeg?resize=624%2C341&amp;ssl=1 624w\" sizes=\"auto, (max-width: 625px) 100vw, 625px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/endocrinedisruption.org\/interactive-tools\/publications\/\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">https:\/\/endocrinedisruption.org\/interactive-tools\/publications\/<\/span><\/a><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><b>Endocrine Disruption<\/b><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">At TEDX we published scientific reviews, commentaries, and original research. Many of our publications were conducted in collaboration with other scientists. We used our expertise to answer important research questions and support informed decision making. Our work is used by government and non-government organizations to protect health by reducing harmful chemicals in our indoor and outdoor environments, and the womb.<\/span><\/p>\n<div class=\"pub-list\">\n<h3><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">2019<\/span><\/h3>\n<div id=\"pub0\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">A scoping review of the health and toxicological activity of bisphenol A (BPA) structural analogues and functional alternatives<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Pelch K, Wignall JA, Goldstone AE, Ross PK, Blain RB, Shapiro AJ, Holmgren SD, Hsieh JH, Svodboda D, Auerbach SS, Parham FM, Masten SA, Walker V, Rooney A, Thayer KA. 2019.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Recent studies report widespread usage or exposure to a variety of chemicals with structural or functional similarity to bisphenol A (BPA), referred to as BPA analogues or derivatives. These have been detected in foodstuffs, house dust, environmental samples, human urine or blood, and consumer products. Compared to BPA, relatively little is known about potential toxicity of these compounds. This scoping review aimed to summarize the human, animal, and mechanistic toxicity data for 24 BPA analogues of emerging interest to research and regulatory communities. PubMed was searched from March 1, 2015 to January 5, 2019 and combined with the results obtained from literature searches conducted through March 23, 2015, in The National Toxicology Program&#8217;s Research Report 4 (NTP RR-04), &#8220;Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives&#8221;. Study details are presented in interactive displays using Tableau Public. In total, 5748 records were screened for inclusion. One hundred sixty seven studies were included from NTP RR-04 and 175 studies were included from the updated literature search through January 2019. In total, there are 22, 117, and 221 human epidemiological, experimental animal, or in vitro studies included. The most frequently studied BPA analogues are bisphenol S (BPS), bisphenol F (4,4-BPF), and bisphenol AF (BPAF). Notable changes in the literature since 2015 include the growing body of human epidemiological studies and in vivo studies conducted in zebrafish. Numerous new endpoints were also evaluated across all three evidence streams including diabetes, obesity, and oxidative stress. However, few studies have addressed endpoints such as neurodevelopmental outcomes or impacts on the developing mammary or prostate glands, which are known to be susceptible to disruption by BPA. Further, there remains a critical need for better exposure information in order to prioritize experimental studies. Moving forward, researchers should also ensure that full dose responses are performed for all main effects in order to support hazard and risk characterization efforts. The evidence gathered here suggests that hazard and risk characterizations should expand beyond BPA in order to consider BPA structural and functional analogues.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31201879\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<\/div>\n<div><\/div>\n<div id=\"pub1\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Characterization of estrogenic and androgenic activities for bisphenol A-like chemicals (BPs): In vitro estrogen and androgen receptors transcriptional activation, gene regulation, and binding profiles<\/span><\/em><\/p>\n<p class=\"pub-title\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Pelch KE, Li Y, Perera L, Thayer KA, Korach KS. 2019.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Bisphenol A (BPA) is a high production volume chemical widely used in plastics, food packaging, and many other products. It is well known that endocrine-disrupting chemicals (EDC) might be harmful to human health due to interference with normal hormone actions. Recent studies report widespread usage and exposure to many BPA-like chemicals (BPs) that are structurally or functionally similar to BPA. However, the biological actions and toxicity of those BPs are still relatively unknown. To address this data gap, we used <em>in vitro<\/em> cell models to evaluate the ability of twenty-two BPs to induce or inhibit estrogenic and androgenic activity. BPA, Bisphenol AF (BPAF), bisphenol Z (BPZ), bisphenol C (BPC), tetramethyl bisphenol A (TMBPA), bisphenol S (BPS), bisphenol E (BPE), 4,4-bisphenol F (4,4-BPF), bisphenol AP (BPAP), bisphenol B (BPB), tetrachlorobisphenol A (TCBPA), and benzylparaben (PHBB) induced estrogen receptor (ER)\u03b1 and\/or ER\u03b2-mediated activity. With the exception of BPS, TCBPA, and PHBB, these same BPs were also androgen receptor (AR) antagonists. Only three BPs were found to be ER antagonists. Bisphenol P (BPP) selectively inhibited ER\u03b2-mediated activity and 4-(4-phenylmethoxyphenyl)sulfonylphenol (BPS-MPE) and 2,4-bisphenol S (2,4-BPS) selectively inhibited ER\u03b1-mediated activity. None of the BPs induced AR mediated activity. In addition, we identify that the BPs can bind to ER or AR with varying degrees by a molecular modeling analysis. Taken together, these findings help us to understand the molecular mechanism of BPs and further consideration of their usage in consumer products.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"https:\/\/academic.oup.com\/toxsci\/advance-article-abstract\/doi\/10.1093\/toxsci\/kfz173\/5544278?redirectedFrom=fulltext\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<\/div>\n<div><\/div>\n<div id=\"pub2\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">PFAS health effects database: protocol for a systematic evidence map<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Pelch KE, Reade A, Wolffe TAM, Kwiatkowski CF. 2019.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<div id=\"as0005\">\n<h3 id=\"st0010\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Background<\/span><\/h3>\n<p id=\"sp0040\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><em>Per<\/em>&#8211; and polyfluoroalkyl substances (PFAS) confer waterproof, greaseproof, and non-stick properties when added to consumer products. They are also used for industrial purposes including in aqueous film forming foams for firefighting. PFAS are ubiquitous in the environment, are widely detected in human biomonitoring studies, and are of growing regulatory concern across federal, state, and local governments. Regulators, scientists, and citizens need to stay informed on the growing health and toxicology literature related to PFAS.<\/span><\/p>\n<\/div>\n<div id=\"as0010\">\n<h3 id=\"st0015\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Objectives<\/span><\/h3>\n<p id=\"sp0045\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">The goal of this systematic evidence map is to identify and organize the available health and toxicology related literature on a set of 29 PFAS of emerging and growing concern.<\/span><\/p>\n<\/div>\n<div id=\"as0015\">\n<h3 id=\"st0020\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Search and study eligibility<\/span><\/h3>\n<p id=\"sp0050\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">We will search the electronic database PubMed for health or toxicological studies on 29 PFAS of emerging concern. Eligible studies must contain primary research investigating the link between one or more of the PFAS of interest and a health effect, toxicological, or biological mechanistic endpoint.<\/span><\/p>\n<\/div>\n<div id=\"as0020\">\n<h3 id=\"st0025\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Study appraisal and synthesis methods<\/span><\/h3>\n<p id=\"sp0055\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Title and abstract screening and full text review will require a single reviewer for inclusion to the next level and two independent reviewers for exclusion. Study quality will not be conducted for this evidence mapping. Study characteristics will be extracted and coded from the included studies and checked for accuracy by a second reviewer. The extracted and coded information will be visualized in a publicly available, interactive database hosted on Tableau Public. Results of the evidence mapping will be published in a narrative summary.<\/span><\/p>\n<\/div>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0160412019305380\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<div><\/div>\n<\/div>\n<div id=\"pub3\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Environmental chemicals and autism: a scoping review of the human and animal research<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Pelch KE, Bolden AL, Kwiatkowski CF. 2019.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<h3 id=\"d3e196\" class=\"article-section__title to-section\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Background:<\/span><\/h3>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Estimates of autism prevalence have increased dramatically over the past two decades. Evidence suggests environmental factors may contribute to the etiology of the disorder.<\/span><\/p>\n<h3 id=\"d3e205\" class=\"article-section__title to-section\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Objectives:<\/span><\/h3>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">This scoping review aimed to identify and categorize primary research and reviews on the association between prenatal and early postnatal exposure to environmental chemicals and the development of autism in epidemiological studies and rodent models of autism.<\/span><\/p>\n<h3 id=\"d3e214\" class=\"article-section__title to-section\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Methods:<\/span><\/h3>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">PubMed was searched through 8 February 2018. Included studies assessed exposure to environmental chemicals prior to 2 months of age in humans or 14 d in rodents. Rodent studies were considered relevant if they included at least one measurement of reciprocal social communicative behavior or repetitive and stereotyped behavior. Study details are presented in interactive displays using Tableau Public.<\/span><\/p>\n<h3 id=\"d3e223\" class=\"article-section__title to-section\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Results:<\/span><\/h3>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">The search returned 21,603 unique studies, of which 54 epidemiological studies, 46 experimental rodent studies, and 50 reviews were deemed relevant, covering 152 chemical exposures. The most frequently studied exposures in humans were particulate matter (<span class=\"equationTd inline-formula\"><span id=\"MathJax-Element-1-Frame\" class=\"MathJax\" tabindex=\"0\" role=\"presentation\" data-mathml=\"&lt;math xmlns=&quot;http:\/\/www.w3.org\/1998\/Math\/MathML&quot; alttext=&quot;n equals 14&quot; display=&quot;inline&quot; overflow=&quot;scroll&quot;&gt;&lt;mrow&gt;&lt;mi&gt;n&lt;\/mi&gt;&lt;mo&gt;=&lt;\/mo&gt;&lt;mn&gt;14&lt;\/mn&gt;&lt;\/mrow&gt;&lt;\/math&gt;\"><span id=\"MathJax-Span-1\" class=\"math\" aria-label=\"n equals 14\"><span id=\"MathJax-Span-2\" class=\"mrow\"><span id=\"MathJax-Span-3\" class=\"mrow\"><span id=\"MathJax-Span-4\" class=\"mi\">n<\/span><span id=\"MathJax-Span-5\" class=\"mo\">=<\/span><span id=\"MathJax-Span-6\" class=\"mn\">14<\/span><\/span><\/span><\/span><\/span><\/span>), mercury (<span class=\"equationTd inline-formula\"><span id=\"MathJax-Element-2-Frame\" class=\"MathJax\" tabindex=\"0\" role=\"presentation\" data-mathml=\"&lt;math xmlns=&quot;http:\/\/www.w3.org\/1998\/Math\/MathML&quot; alttext=&quot;n equals 14&quot; display=&quot;inline&quot; overflow=&quot;scroll&quot;&gt;&lt;mrow&gt;&lt;mi&gt;n&lt;\/mi&gt;&lt;mo&gt;=&lt;\/mo&gt;&lt;mn&gt;14&lt;\/mn&gt;&lt;\/mrow&gt;&lt;\/math&gt;\"><span id=\"MathJax-Span-7\" class=\"math\" aria-label=\"n equals 14\"><span id=\"MathJax-Span-8\" class=\"mrow\"><span id=\"MathJax-Span-9\" class=\"mrow\"><span id=\"MathJax-Span-10\" class=\"mi\">n<\/span><span id=\"MathJax-Span-11\" class=\"mo\">=<\/span><span id=\"MathJax-Span-12\" class=\"mn\">14<\/span><\/span><\/span><\/span><\/span><\/span>), nonspecific air pollution (<span class=\"equationTd inline-formula\"><span id=\"MathJax-Element-3-Frame\" class=\"MathJax\" tabindex=\"0\" role=\"presentation\" data-mathml=\"&lt;math xmlns=&quot;http:\/\/www.w3.org\/1998\/Math\/MathML&quot; alttext=&quot;n equals 10&quot; display=&quot;inline&quot; overflow=&quot;scroll&quot;&gt;&lt;mrow&gt;&lt;mi&gt;n&lt;\/mi&gt;&lt;mo&gt;=&lt;\/mo&gt;&lt;mn&gt;10&lt;\/mn&gt;&lt;\/mrow&gt;&lt;\/math&gt;\"><span id=\"MathJax-Span-13\" class=\"math\" aria-label=\"n equals 10\"><span id=\"MathJax-Span-14\" class=\"mrow\"><span id=\"MathJax-Span-15\" class=\"mrow\"><span id=\"MathJax-Span-16\" class=\"mi\">n<\/span><span id=\"MathJax-Span-17\" class=\"mo\">=<\/span><span id=\"MathJax-Span-18\" class=\"mn\">10<\/span><\/span><\/span><\/span><\/span><\/span>), and lead (<span class=\"equationTd inline-formula\"><span id=\"MathJax-Element-4-Frame\" class=\"MathJax\" tabindex=\"0\" role=\"presentation\" data-mathml=\"&lt;math xmlns=&quot;http:\/\/www.w3.org\/1998\/Math\/MathML&quot; alttext=&quot;n equals 10&quot; display=&quot;inline&quot; overflow=&quot;scroll&quot;&gt;&lt;mrow&gt;&lt;mi&gt;n&lt;\/mi&gt;&lt;mo&gt;=&lt;\/mo&gt;&lt;mn&gt;10&lt;\/mn&gt;&lt;\/mrow&gt;&lt;\/math&gt;\"><span id=\"MathJax-Span-19\" class=\"math\" aria-label=\"n equals 10\"><span id=\"MathJax-Span-20\" class=\"mrow\"><span id=\"MathJax-Span-21\" class=\"mrow\"><span id=\"MathJax-Span-22\" class=\"mi\">n<\/span><span id=\"MathJax-Span-23\" class=\"mo\">=<\/span><span id=\"MathJax-Span-24\" class=\"mn\">10<\/span><\/span><\/span><\/span><\/span><\/span>). In rodent studies, the most frequently studied exposures were chlorpyrifos (<span class=\"equationTd inline-formula\"><span id=\"MathJax-Element-5-Frame\" class=\"MathJax\" tabindex=\"0\" role=\"presentation\" data-mathml=\"&lt;math xmlns=&quot;http:\/\/www.w3.org\/1998\/Math\/MathML&quot; alttext=&quot;n equals 9&quot; display=&quot;inline&quot; overflow=&quot;scroll&quot;&gt;&lt;mrow&gt;&lt;mi&gt;n&lt;\/mi&gt;&lt;mo&gt;=&lt;\/mo&gt;&lt;mn&gt;9&lt;\/mn&gt;&lt;\/mrow&gt;&lt;\/math&gt;\"><span id=\"MathJax-Span-25\" class=\"math\" aria-label=\"n equals 9\"><span id=\"MathJax-Span-26\" class=\"mrow\"><span id=\"MathJax-Span-27\" class=\"mrow\"><span id=\"MathJax-Span-28\" class=\"mi\">n<\/span><span id=\"MathJax-Span-29\" class=\"mo\">=<\/span><span id=\"MathJax-Span-30\" class=\"mn\">9<\/span><\/span><\/span><\/span><\/span><\/span>), mercury (<span class=\"equationTd inline-formula\"><span id=\"MathJax-Element-6-Frame\" class=\"MathJax\" tabindex=\"0\" role=\"presentation\" data-mathml=\"&lt;math xmlns=&quot;http:\/\/www.w3.org\/1998\/Math\/MathML&quot; alttext=&quot;n equals 6&quot; display=&quot;inline&quot; overflow=&quot;scroll&quot;&gt;&lt;mrow&gt;&lt;mi&gt;n&lt;\/mi&gt;&lt;mo&gt;=&lt;\/mo&gt;&lt;mn&gt;6&lt;\/mn&gt;&lt;\/mrow&gt;&lt;\/math&gt;\"><span id=\"MathJax-Span-31\" class=\"math\" aria-label=\"n equals 6\"><span id=\"MathJax-Span-32\" class=\"mrow\"><span id=\"MathJax-Span-33\" class=\"mrow\"><span id=\"MathJax-Span-34\" class=\"mi\">n<\/span><span id=\"MathJax-Span-35\" class=\"mo\">=<\/span><span id=\"MathJax-Span-36\" class=\"mn\">6<\/span><\/span><\/span><\/span><\/span><\/span>), and lead (<span class=\"equationTd inline-formula\"><span id=\"MathJax-Element-7-Frame\" class=\"MathJax\" tabindex=\"0\" role=\"presentation\" data-mathml=\"&lt;math xmlns=&quot;http:\/\/www.w3.org\/1998\/Math\/MathML&quot; alttext=&quot;n equals 4&quot; display=&quot;inline&quot; overflow=&quot;scroll&quot;&gt;&lt;mrow&gt;&lt;mi&gt;n&lt;\/mi&gt;&lt;mo&gt;=&lt;\/mo&gt;&lt;mn&gt;4&lt;\/mn&gt;&lt;\/mrow&gt;&lt;\/math&gt;\"><span id=\"MathJax-Span-37\" class=\"math\" aria-label=\"n equals 4\"><span id=\"MathJax-Span-38\" class=\"mrow\"><span id=\"MathJax-Span-39\" class=\"mrow\"><span id=\"MathJax-Span-40\" class=\"mi\">n<\/span><span id=\"MathJax-Span-41\" class=\"mo\">=<\/span><span id=\"MathJax-Span-42\" class=\"mn\">4<\/span><\/span><\/span><\/span><\/span><\/span>).<\/span><\/p>\n<h3 id=\"d3e303\" class=\"article-section__title to-section\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Discussion:<\/span><\/h3>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Although research is growing rapidly, wide variability exists in study design and conduct, exposures investigated, and outcomes assessed. Conclusions focus on recommendations to guide development of best practices in epidemiology and toxicology, including greater harmonization across these fields of research to more quickly and efficiently identify chemicals of concern. In particular, we recommend chlorpyrifos, lead, and polychlorinated biphenyls (PCBs) be systematically reviewed in order to assess their relationship with the development of autism. There is a pressing need to move forward quickly and efficiently to understand environmental influences on autism in order to answer current regulatory questions and inform treatment and prevention efforts. <a class=\"references__uri\" href=\"https:\/\/doi.org\/10.1289\/EHP4386\">https:\/\/doi.org\/10.1289\/EHP4386<\/a><\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"https:\/\/ehp.niehs.nih.gov\/doi\/10.1289\/EHP4386\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<div><\/div>\n<\/div>\n<h3><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">2018<\/span><\/h3>\n<div id=\"pub4\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Protocol for a systematic map of the evidence of migrating and extractable chemicals from food contact articles<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Martin OV, Geueke B, Groh KJ, Chevrier J, Fini JB, Houlihan J, Kassotis C, Myers P, Nagel SC, Pelch KE, Sargis RM, Trasande L, Vandenberg LN, Wagner M, Maffini MV, Muncke J. 2018.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Final protocol uploaded to Zenodo and attributed the following digital object identifier (DOI) 10.5281\/zenodo.2525277.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Introduction:<\/strong><\/span><\/p>\n<p><span class=\"noSpaceAbove\" style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Rationale<\/strong><\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Approximately 10,000 substances are intentionally used in the manufacture of food contact materials (FCMs), and an estimated 40,000 to 100,000 substances are thought to be present in all different types of food contact articles (FCAs) (Grob et al. 2006). FCMs and FCAs come into direct contact with foodstuffs; their chemical constituents, food contact chemicals (FCCs), can be transferred into food by the process of chemical migration (Arvanitoyannis and Bosnea 2004). Since almost all foodstuffs come into contact with FCAs during their production, storage, processing<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">and\/or packaging, there is most likely wide exposure of the human population to FCCs (Muncke et al. 2014). However, the extent of this exposure, and the variability of exposure between individuals and populations, is essentially unknown. Further, the human health effects related to chronic, low-level chemical exposures via food are poorly understood, and the available scientific evidence mostly<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">focuses on a few very well studied FCCs which are known chemicals of concern such as bisphenol A, ortho-phthalates, and perfluorooctanoic acid (Muncke et al. 2017; Trasande et al. 2018).<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">More research is needed to better understand the relationships between FCC exposures and human health effects. As a first step, completion of this protocol will allow us to compile the available scientific evidence about chemical migration from and\/or extractable from FCAs. Follow-up studies not described in this protocol, but based on the outcome of this work, will address human exposure to FCCs, as well as the human health outcomes implicated with human exposure to FCCs, in order to<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">characterize the state-of-the-science and identify key knowledge gaps. The focus of this work is on indirect food additives and it excludes all chemicals intentionally added to food (e.g. food additives) or unintentionally added to food through a process unrelated to FCA (e.g. pesticides, herbicides, etc).<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"https:\/\/zenodo.org\/record\/2525277#.XC4skM17mUl\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<\/div>\n<div><\/div>\n<div id=\"pub5\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Exploring the endocrine activity of air pollutants associated with unconventional oil and gas extraction<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Bolden AL, Schultz K, Pelch KE, Kwiatkowski CF. 2018.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Background:<\/strong> In the last decade unconventional oil and gas (UOG) extraction has rapidly proliferated throughout the United States (US) and the world. This occurred largely because of the development of directional drilling and hydraulic fracturing which allows access to fossil fuels from geologic formations that were previously not cost effective to pursue. This process is known to use greater than 1,000 chemicals such as solvents, surfactants, detergents, and biocides. In addition, a complex mixture of chemicals, including heavy metals, naturally-occurring radioactive chemicals, and organic compounds are released from the formations and can enter air and water. Compounds associated with UOG activity have been linked to adverse reproductive and developmental outcomes in humans and laboratory animal models, which is possibly due to the presence of endocrine active chemicals.<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Methods:<\/strong> Using systematic methods, electronic searches of PubMed and Web of Science were conducted to identify studies that measured chemicals in air near sites of UOG activity. Records were screened by title and abstract, relevant articles then underwent full text review, and data were extracted from the studies. A list of<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">chemicals detected near UOG sites was generated. Then, the potential endocrine activity of the most frequently detected chemicals was explored via searches of literature from PubMed.<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Results:<\/strong> Evaluation of 48 studies that sampled air near sites of UOG activity identified 106 chemicals detected in two or more studies. Ethane, benzene and n-pentane were the top three most frequently detected. Twenty-one chemicals have been shown to have endocrine activity including estrogenic and androgenic activity and the ability to alter steroidogenesis. Literature also suggested that some of the air pollutants may affect reproduction, development, and neurophysiological function, all endpoints which can be modulated by hormones. These chemicals included aromatics (i.e., benzene, toluene, ethylbenzene, and xylene), several polycyclic aromatic hydrocarbons, and mercury.<\/span><br \/>\n<span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Conclusion:<\/strong> These results provide a basis for prioritizing future primary studies regarding the endocrine disrupting properties of UOG air pollutants, including exposure research in wildlife and humans. Further, we recommend systematic reviews of the health impacts of exposure to specific chemicals, and comprehensive environmental sampling of a broader array of chemicals.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29558955\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<div><\/div>\n<\/div>\n<div id=\"pub6\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Prenatal exposure to bisphenol A and hyperactivity in children: a systematic review and meta-analysis<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Rochester JR, Bolden AB, Kwiatkowski CF. 2018.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Background<\/strong>: Attention-deficit hyperactivity disorder (ADHD) has increased in prevalence in the past decade. Studies attempting to identify a specific genetic component have not been able to account for much of the heritability of ADHD, indicating there may be gene-environment interactions underlying the disorder, including early exposure to environmental chemicals. Based on several relevant studies, we chose to examine bisphenol A (BPA) as a possible contributor to ADHD in humans. BPA is a widespread environmental chemical that has been shown to disrupt neurodevelopment in rodents and humans.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Objectives<\/strong>: Using the Office of Health Assessment and Translation (OHAT) framework, a systematic review and <a href=\"https:\/\/www.sciencedirect.com\/topics\/earth-and-planetary-sciences\/meta-analysis\" target=\"_blank\" rel=\"noopener noreferrer\">meta-analysis<\/a> was designed to determine the relationship between early life exposure to BPA and hyperactivity, a key diagnostic criterion of ADHD.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Data sources<\/strong>: Searches of PubMed, Web of Science, and Toxline were completed for all literature to January 1, 2017.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Study eligibility criteria<\/strong>: For inclusion, the studies had to publish original data, be in the English language, include a measure of BPA exposure, and assess if BPA exposure affected hyperactive behaviors in mice, rats or humans. Exposure to BPA had to occur at &lt;3\u202fmonths of age for humans, up to postnatal day 35 for rats and up to postnatal day 40 for mice. Exposure could occur either gestationally (via maternal exposure) or directly to the offspring.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Study appraisal and synthesis methods<\/strong>: Studies were evaluated using the OHAT risk of bias tool. The effects in humans were assessed qualitatively. For rodents exposed to 20\u202f\u03bcg\/kg\/day BPA, we evaluated the study findings in a random effects meta-analytical model.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Results<\/strong>: A review of the literature identified 29 rodent and 3 human studies. A random effects meta-analysis showed significantly increased hyperactivity in male rodents. In humans, early BPA exposure was associated with hyperactivity in boys and girls.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Limitations, conclusions, and implications of key findings<\/strong>: We concluded that early life BPA exposure is a presumed human hazard for the development of hyperactivity. Possible limitations of this systematic review include deficiencies in author reporting, exclusion of some literature based on language, and insufficient similarity between human studies. SRs that result in hazard-based conclusions are the first step in assessing and mitigating risks. Given the widespread exposure of BPA and increasing diagnoses of ADHD, we recommend immediate actions to complete such risk analyses and take next steps for the protection of human health. In the meantime, precautionary measures should be taken to reduce exposure in pregnant women, infants and children. The present analysis also discusses potential mechanisms by which BPA affects hyperactivity, and the most effective avenues for future research.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0160412017311960\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<\/div>\n<h3><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">2017<\/span><\/h3>\n<div id=\"pub7\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Is it time to reassess current safety standards for glyphosate-based herbicides?<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Vandenberg LN, Blumberg B, Antoniou MN, Benbrook CM, Carroll L, Colborn T, Everett LG, Hansen M, Landrigan PJ, Lanphear BP, Mesnage R, Vom Saal FS, Welshons WV, Myers JP. 2017.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Use of glyphosate-based herbicides (GBHs) increased \u223c100-fold from 1974 to 2014. Additional increases are expected due to widespread emergence of glyphosate-resistant weeds, increased application of GBHs, and preharvest uses of GBHs as desiccants. Current safety assessments rely heavily on studies conducted over 30\u2005years ago. We have considered information on GBH use, exposures, mechanisms of action, toxicity and epidemiology. Human exposures to glyphosate are rising, and a number of in vitro and in vivo studies challenge the basis for the current safety assessment of glyphosate and GBHs. We conclude that current safety standards for GBHs are outdated and may fail to protect public health or the environment. To improve safety standards, the following are urgently needed: (1) human biomonitoring for glyphosate and its metabolites; (2) prioritisation of glyphosate and GBHs for hazard assessments, including toxicological studies that use state-of-the-art approaches; (3) epidemiological studies, especially of occupationally exposed agricultural workers, pregnant women and their children and (4) evaluations of GBHs in commercially used formulations, recognising that herbicide mixtures likely have effects that are not predicted by studying glyphosate alone.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"http:\/\/jech.bmj.com\/content\/71\/6\/613\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<div><\/div>\n<\/div>\n<div id=\"pub8\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Potential developmental and reproductive impacts of triclocarban: A scoping review<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Rochester JR, Bolden AL, Pelch KE, Kwiatkowski CF. 2017.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Triclocarban (TCC) is an antimicrobial agent used in personal care products. Although frequently studied with another antimicrobial, triclosan, it is not as well researched, and there are very few reviews of the biological activity of TCC. TCC has been shown to be a possible endocrine disruptor, acting by enhancing the activity of endogenous hormones. TCC has been banned in the US for certain applications; however, many human populations, in and outside the US, exhibit exposure to TCC. Because of the concern of the health effects of TCC, we conducted a scoping review in order to map the current body of literature on the endocrine, reproductive, and developmental effects of TCC. The aim of this scoping review was to identify possible endpoints for future systematic review and to make recommendations for future research. A search of the literature until August 2017 yielded 32 relevant studies in humans, rodents, fish, invertebrates, and in vitro. Based on the robustness of the literature in all three evidence streams (human, animal, and in vitro), we identified three endpoints for possible systematic review: estrogenic activity, androgenic activity, and offspring growth. In this review, we describe the body of evidence and make recommendations for future research.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"https:\/\/www.hindawi.com\/journals\/jt\/2017\/9679738\/\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<div><\/div>\n<\/div>\n<div id=\"pub9\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Melamine, beyond the kidney: A ubiquitous endocrine disruptor and neurotoxicant?<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Bolden AL, Rochester JR, Kwiatkowski CF. 2017.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Melamine is commonly used in a variety of consumer products such as furniture, dining ware, and food utensils. The chemical infamously gained worldwide attention by its illegal addition to a variety of foodstuffs in order to falsify protein content, which led to serious, sometimes fatal, health impacts in children and pets. This resulted in a large amount of published primary studies and reviews of the impacts of melamine exposure on kidney function. However, a growing body of literature suggests that melamine may have impacts beyond renal dysfunction. We conducted a scoping review of this literature which yielded more than 40 studies with human, animal, and <em>in vitro<\/em> findings. Neurological impacts, reproductive function, and anthropometric outcomes were identified as possible candidates for systematic review based on evidence stream and replication of endpoints. The results of this analysis provide a basis for prioritizing future research on health impacts associated with melamine exposure.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378427417311396\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<div><\/div>\n<\/div>\n<div id=\"pub10\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Polycyclic aromatic hydrocarbons and female reproductive health: A scoping review<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Bolden AL, Rochester JR, Schultz K, Kwiatkowski CF. 2017.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Polycyclic aromatic hydrocarbons (PAHs) are a class of common persistent environmental pollutants found in water, air, soil, and plants and can be released by natural sources. However, the majority of atmospheric PAHs are from vehicular emissions, coal-burning plants, and the production and use of petroleum-derived substances. Exposure to PAHs has been implicated in cancer and other diseases, including reproductive disorders. This scoping review is a preliminary step that explores the utility and feasibility of completing a systematic review evaluating the effect of PAHs on female reproduction. We performed literature searches in PubMed, Web of Science, and Scopus, then screened, identified, and categorized relevant studies. Our results identified fertility and pregnancy\/fetal viability as outcomes with sufficient research for systematic review. In addition to presenting the relevant studies, the review identifies data gaps, and provides the groundwork to develop the most appropriate research questions for systematic review.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0890623816304397\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<div><\/div>\n<\/div>\n<div id=\"pub11\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">The Age of Chemicals in the 21st Century: New Inventions, New Problems<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Kwiatkowski, CF. 2017.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Dr. Kwiatkowski wrote the introductory chapter to the book Integrative Environmental Medicine, edited by Aly Cohen and Frederick vom Saal. The book shares the full story of environmental medicine, from the history of plastics and chemicals, to regulatory failures, to the health consequences of water and air contamination and the rising incidence of disease in the U.S. It also offers tangible, practical information that can easily be integrated into the daily work flow of patient clinical care; websites, phone apps, physician and patient handouts and printable lists.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"https:\/\/global.oup.com\/academic\/product\/integrative-environmental-medicine-9780190490911?cc=us&amp;lang=en&amp;\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<div><\/div>\n<\/div>\n<h3><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">2016<\/span><\/h3>\n<div id=\"pub12\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Twenty-Five Years of Endocrine Disruption Science: Remembering Theo Colborn<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Kwiatkowski CF, Bolden AL, Liroff RA, Rochester JR, Vandenbergh JG. 2016.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">For nearly 30 years, Dr. Theo Colborn (1927\u20132014) dedicated herself to studying the harmful effects of endocrine-disrupting chemicals on wildlife, humans, and the environment. More recently, she extended this effort to address the health impacts of unconventional oil and gas development. Colborn was a visionary leader who excelled at synthesizing scientific findings across disciplines. Using her unique insights and strong moral convictions, she changed the face of toxicological research, influenced chemical regulatory policy, and educated the public. In 2003, Colborn started a nonprofit organization\u2014The Endocrine Disruption Exchange (TEDX). As we celebrate the 25th anniversary of endocrine disruption science, TEDX continues her legacy of analyzing the extensive body of environmental health research and developing unique educational resources to support public policy and education. Among other tools, TEDX currently uses the systematic review framework developed by the National Toxicology Program at the National Institute of Environmental Health Sciences, to answer research questions of pressing concern. In this article, we pay homage to the tenacious woman and the exemplary contribution she made to the field of environmental health. Recommendations for the future of the field are drawn from her wisdom.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"https:\/\/ehp.niehs.nih.gov\/ehp746\/\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<div><\/div>\n<\/div>\n<div id=\"pub13\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Minireview: Endocrine Disruptors: Past Lessons and Future Directions<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Schug TT, Johnson AF, Birnbaum LS, Colborn T, Guillette LJ, Crews DP, Collins T, Soto AM, vom Saal FS, McLachlan JA, Sonnenschein C, Heindel JJ. 2016.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Within the past few decades, the concept of endocrine-disrupting chemicals (EDCs) has risen from a position of total obscurity to become a focus of dialogue, debate, and concern among scientists, physicians, regulators, and the public. The emergence and development of this field of study has not always followed a smooth path, and researchers continue to wrestle with questions about the low-dose effects and nonmonotonic dose responses seen with EDCs, their biological mechanisms of action, the true pervasiveness of these chemicals in our environment and in our bodies, and the extent of their effects on human and wildlife health. This review chronicles the development of the unique, multidisciplinary field of endocrine disruption, highlighting what we have learned about the threat of EDCs and lessons that could be relevant to other fields. It also offers perspectives on the future of the field and opportunities to better protect human health.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"https:\/\/academic.oup.com\/mend\/article-abstract\/30\/8\/833\/2747295\/Minireview-Endocrine-Disruptors-Past-Lessons-and\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<div><\/div>\n<\/div>\n<div id=\"pub14\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Project TENDR: Targeting Environmental Neuro-Developmental Risks. The TENDR Consensus Statement<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Bennett D, Bellinger DC, Birnbaum LS, Bradman A, Chen A, Cory-Slechta DA, Engel SM, Fallin MD, Halladay A, Hauser R, Hertz-Picciotto I, Kwiatkowski CF, Lanphear BP, Marquez E, Marty M, McPartland J, Newschaffer CJ, Payne-Sturges D, Patisaul HB, Perera FP, Ritz B, Sass J, Schantz SL, Webster TF, Whyatt RM, Woodruff TJ, Zoeller RT, Anderko L, Campbell C, Conry JA, DeNicola N, Gould RM, Hirtz D, Huffling K, Landrigan PJ, Lavin A, Miller M, Mitchell MA, Rubin L, Schettler T, Tran HL, Acosta A, Brody C, Miller E, Miller P, Swanson M, Witherspoon NO. 2016.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Summary:\u00a0<\/strong>Children in America today are at an unacceptably high risk of developing neurodevelopmental disorders that affect the brain and nervous system including autism, attention deficit hyperactivity disorder, intellectual disabilities, and other learning and behavioral disabilities. These are complex disorders with multiple causes\u2014genetic, social, and environmental. The contribution of toxic chemicals to these disorders can be prevented.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Approach:<\/strong> Leading scientific and medical experts, along with children\u2019s health advocates, came together in 2015 under the auspices of Project TENDR: Targeting Environmental Neuro-Developmental Risks to issue a call to action to reduce widespread exposures to chemicals that interfere with fetal and children\u2019s brain development. Based on the available scientific evidence, the TENDR authors have identified prime examples of toxic chemicals and pollutants that increase children\u2019s risks for neurodevelopmental disorders. These include chemicals that are used extensively in consumer products and that have become widespread in the environment. Some are chemicals to which children and pregnant women are regularly exposed, and they are detected in the bodies of virtually all Americans in national surveys conducted by the U.S. Centers for Disease Control and Prevention. The vast majority of chemicals in industrial and consumer products undergo almost no testing for developmental neurotoxicity or other health effects.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Conclusion<\/strong>: Based on these findings, we assert that the current system in the United States for evaluating scientific evidence and making health-based decisions about environmental chemicals is fundamentally broken. To help reduce the unacceptably high prevalence of neurodevelopmental disorders in our children, we must eliminate or significantly reduce exposures to chemicals that contribute to these conditions. We must adopt a new framework for assessing chemicals that have the potential to disrupt brain development and prevent the use of those that may pose a risk. This consensus statement lays the foundation for developing recommendations to monitor, assess, and reduce exposures to neurotoxic chemicals. These measures are urgently needed if we are to protect healthy brain development so that current and future generations can reach their fullest potential. \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"https:\/\/ehp.niehs.nih.gov\/ehp358\/\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<div><\/div>\n<\/div>\n<div id=\"pub15\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Concerns Over Use of Glyphosate-based Herbicides and Risks Associated with Exposures: A Consensus Statement<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Myers JP, Antoniou MN, Blumberg B, Carroll L, Colborn T, Everett LG, Hansen M, Landrigan PJ, Lanphear BP, Mesnage R, et al. 2016.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">The broad-spectrum herbicide glyphosate (common trade name \u201cRoundup\u201d) was first sold to farmers in 1974. Since the late 1970s, the volume of glyphosate-based herbicides (GBHs) applied has increased approximately 100-fold. Further increases in the volume applied are likely due to more and higher rates of application in response to the widespread emergence of glyphosate-resistant weeds and new, pre-harvest, dessicant use patterns. GBHs were developed to replace or reduce reliance on herbicides causing well-documented problems associated with drift and crop damage, slipping efficacy, and human health risks. Initial industry toxicity testing suggested that GBHs posed relatively low risks to non-target species, including mammals, leading regulatory authorities worldwide to set high acceptable exposure limits. To accommodate changes in GBH use patterns associated with genetically engineered, herbicide-tolerant crops, regulators have dramatically increased tolerance levels in maize, oilseed (soybeans and canola), and alfalfa crops and related livestock feeds. Animal and epidemiology studies published in the last decade, however, point to the need for a fresh look at glyphosate toxicity. Furthermore, the World Health Organization\u2019s International Agency for Research on Cancer recently concluded that glyphosate is \u201cprobably carcinogenic to humans.\u201d In response to changing GBH use patterns and advances in scientific understanding of their potential hazards, we have produced a Statement of Concern drawing on emerging science relevant to the safety of GBHs.\u00a0Our Statement of Concern considers current published literature describing GBH uses, mechanisms of action, toxicity in laboratory animals, and epidemiological studies. It also examines the derivation of current human safety standards. We conclude that: (1) GBHs are the most heavily applied herbicide in the world and usage continues to rise; (2) Worldwide, GBHs often contaminate drinking water sources, precipitation, and air, especially in agricultural regions; (3) The half-life of glyphosate in water and soil is longer than previously recognized; (4) Glyphosate and its metabolites are widely present in the global soybean supply; (5) Human exposures to GBHs are rising; (6) Glyphosate is now authoritatively classified as a probable human carcinogen; (7) Regulatory estimates of tolerable daily intakes for glyphosate in the United States and European Union are based on outdated science. We offer a series of recommendations related to the need for new investments in epidemiological studies, biomonitoring, and toxicology studies that draw on the principles of endocrinology to determine whether the effects of GBHs are due to endocrine disrupting activities. We suggest that common commercial formulations of GBHs should be prioritized for inclusion in government-led toxicology testing programs such as the U.S. National Toxicology Program, as well as for biomonitoring as conducted by the U.S. Centers for Disease Control and Prevention.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"https:\/\/ehjournal.biomedcentral.com\/articles\/10.1186\/s12940-016-0117-0\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<\/div>\n<h3><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">2010\u20132015<\/span><\/h3>\n<div id=\"pub16\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">New Look at BTEX: Are Ambient Levels a Problem?<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Bolden AL, Kwiatkowski C, Colborn T. 2015.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Benzene, toluene, ethylbenzene, and xylene (BTEX) are retrieved during fossil fuel extraction and used as solvents in consumer and industrial products, as gasoline additives, and as intermediates in the synthesis of organic compounds for many consumer products. Emissions from the combustion of gasoline and diesel fuels are the largest contributors to atmospheric BTEX concentrations. However, levels indoors (where people spend greater than 83% of their time) can be many times greater than outdoors. In this review we identified epidemiological studies assessing the noncancer health impacts of ambient level BTEX exposure (i.e., nonoccupational) and discussed how the health conditions may be hormonally mediated. Health effects significantly associated with ambient level exposure included sperm abnormalities, reduced fetal growth, cardiovascular disease, respiratory dysfunction, asthma, sensitization to common antigens, and more. Several hormones including estrogens, androgens, glucocorticoids, insulin, and serotonin may be involved in these health outcomes. This analysis suggests that all four chemicals may have endocrine disrupting properties at exposure levels below reference concentrations (i.e., safe levels) issued by the U.S. Environmental Protection Agency. These data should be considered when evaluating the use of BTEX in consumer and industrial products and indicates a need to change how chemicals present at low concentrations are assessed and regulated.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/es505316f\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<div><\/div>\n<\/div>\n<div id=\"pub17\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Rochester JR, Bolden AL. 2015.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Background:<\/strong> Increasing concern over bisphenol A (BPA) as an endocrine-disrupting chemical and its possible effects on human health have prompted the removal of BPA from consumer products, often labeled \u201cBPA-free.\u201d Some of the chemical replacements, however, are also bisphenols and may have similar physiological effects in organisms. Bisphenol S (BPS) and bisphenol F (BPF) are two such BPA substitutes.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Objectives:<\/strong> This review was carried out to evaluate the physiological effects and endocrine activities of the BPA substitutes BPS and BPF. Further, we compared the hormonal potency of BPS and BPF to that of BPA.<\/span><\/p>\n<p class=\"abstract\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Methods:<\/strong> We conducted a systematic review based on the Office of Health Assessment and Translation (OHAT) protocol.<\/span><\/p>\n<p class=\"abstract\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Results:<\/strong> We identified the body of literature to date, consisting of 32 studies (25 <em>in vitro<\/em> only, and 7 <em>in vivo<\/em>). The majority of these studies examined the hormonal activities of BPS and BPF and found their potency to be in the same order of magnitude and of similar action as BPA (estrogenic, antiestrogenic, androgenic, and antiandrogenic) <em>in vitro<\/em> and <em>in vivo<\/em>. BPS also has potencies similar to that of estradiol in membrane-mediated pathways, which are important for cellular actions such as proliferation, differentiation, and death. BPS and BPF also showed other effects <em>in vitro<\/em> and <em>in vivo<\/em>, such as altered organ weights, reproductive end points, and enzyme expression.<\/span><\/p>\n<p class=\"abstract\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Conclusions:<\/strong> Based on the current literature, BPS and BPF are as hormonally active as BPA, and they have endocrine-disrupting effects.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"https:\/\/ehp.niehs.nih.gov\/1408989\/\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<div><\/div>\n<\/div>\n<div id=\"pub18\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Bisphenol A and Human Health: A Review of the Literature<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Rochester JR. 2013.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">There is growing evidence that bisphenol A (BPA) may adversely affect humans. BPA is an endocrine disruptor that has been shown to be harmful in laboratory animal studies. Until recently, there were relatively few epidemiological studies examining the relationship between BPA and health effects in humans. However, in the last year, the number of these studies has more than doubled. A comprehensive literature search found 91 studies linking BPA to human health; 53 published within the last year. This review outlines this body of literature, showing associations between BPA exposure and adverse perinatal, childhood, and adult health outcomes, including reproductive and developmental effects, metabolic disease, and other health effects. These studies encompass both prenatal and postnatal exposures, and include several study designs and population types. While it is difficult to make causal links with epidemiological studies, the growing human literature correlating environmental BPA exposure to adverse effects in humans, along with laboratory studies in many species including primates, provides increasing support that environmental BPA exposure can be harmful to humans, especially in regards to behavioral and other effects in children.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0890623813003456\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<div><\/div>\n<\/div>\n<div id=\"pub19\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Regulatory Decisions on Endocrine Disrupting Chemicals Should Be Based on the Principles of Endocrinology<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR Jr, Lee DH, Shioda T, Sota AM, Vom Saal FS, Welshons WV, Zoeller RT. 2013.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">For years, scientists from various disciplines have studied the effects of endocrine disrupting chemicals (EDCs) on the health and wellbeing of humans and wildlife. Some studies have specifically focused on the effects of low doses, i.e. those in the range that are thought to be safe for humans and\/or animals. Others have focused on the existence of non-monotonic dose-response curves. These concepts challenge the way that chemical risk assessment is performed for EDCs. Continued discussions have clarified exactly what controversies and challenges remain. We address several of these issues, including why the study and regulation of EDCs should incorporate endocrine principles; what level of consensus there is for low dose effects; challenges to our understanding of non-monotonicity; and whether EDCs have been demonstrated to produce adverse effects. This discussion should result in a better understanding of these issues, and allow for additional dialog on their impact on risk assessment.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0890623813000191\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<div><\/div>\n<\/div>\n<div id=\"pub20\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Hormones and Endocrine-disrupting Chemicals: Low-dose Effects and Nonmonotonic Dose Responses<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR Jr, Lee DH, Shioda T, Soto AM, Vom Saal FS, Welshons WV, Zoeller RT, Myers JP. 2012.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional concepts in toxicology, in particular the dogma of &#8220;the dose makes the poison,&#8221; because EDCs can have effects at low doses that are not predicted by effects at higher doses. Here, we review two major concepts in EDC studies: low dose and nonmonotonicity. Low-dose effects were defined by the National Toxicology Program as those that occur in the range of human exposures or effects observed at doses below those used for traditional toxicological studies. We review the mechanistic data for low-dose effects and use a weight-of-evidence approach to analyze five examples from the EDC literature. Additionally, we explore nonmonotonic dose-response curves, defined as a nonlinear relationship between dose and effect where the slope of the curve changes sign somewhere within the range of doses examined. We provide a detailed discussion of the mechanisms responsible for generating these phenomena, plus hundreds of examples from the cell culture, animal, and epidemiology literature. We illustrate that nonmonotonic responses and low-dose effects are remarkably common in studies of natural hormones and EDCs. Whether low doses of EDCs influence certain human disorders is no longer conjecture, because epidemiological studies show that environmental exposures to EDCs are associated with human diseases and disabilities. We conclude that when nonmonotonic dose-response curves occur, the effects of low doses cannot be predicted by the effects observed at high doses. Thus, fundamental changes in chemical testing and safety determination are needed to protect human health.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"https:\/\/academic.oup.com\/edrv\/article\/33\/3\/378\/2354852\/Hormones-and-Endocrine-Disrupting-Chemicals-Low\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<\/div>\n<h3><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">2004\u20132009<\/span><\/h3>\n<div id=\"pub21\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Re: Good Laboratory Practices and Safety Assessments. [Response to Becker et al., Environmental Health Perspectives 117(11):A482-483]<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Myers JP, vom Saal FS, Akingbemi BT, Arizono K, Belcher S, Colborn T, Chahoud I, Crain DA , Farabollini F, Guillette LJ Jr, Hassold T, Ho SM, Hunt PA, Iguchi T, Jobling S, Kanno J, Laufer H, Marcus M, McLachlan JA, Nadal A, Oehlmann J, Olea N, Palanza P, Parmigiani S, Rubin BS, Schoenfelder G, Sonnenschein C, Soto AM, Talsness CE, Taylor JA, Vandenberg LN, Vandenbergh JG, Vogel S, Watson CS, Welshons WV, Zoeller RT. 2009.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">We are in complete agreement with the statement by Becker et al. that \u201chaving confidence in scientific procedures and data is the <em>sine qua non<\/em> for determining the safety of chemicals and chemical products.\u201d Our aim in writing the commentary (Myers et al. 2009) was not to challenge the original intent of Good Laboratory Practices (GLP) requirements, which was to establish standards of record keeping in contract laboratory research so as to reduce the likelihood of fraud. Our goal instead was to show\u2014through an analysis of the application of GLP data on bisphenol A (BPA) in regulatory proceedings\u2014that GLP by itself is insufficient to guarantee valid and reliable science. Becker et al. appear to have missed the point of our commentary entirely.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"https:\/\/ehp.niehs.nih.gov\/0900884r\/\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<div><\/div>\n<\/div>\n<div id=\"pub22\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Why Public Health Agencies Cannot Depend on Good Laboratory Practices as a Criterion for Selecting Data: The Case of Bisphenol A<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Myers JP, vom Saal FS, Akingbemi BT, Arizono K, Belcher S, Colborn T, Chahoud I, Crain DA , Farabollini F, Guilleffe LJ, Hassold T, Ho SM, Hunt PA, Iguchi T, Jobling S, Kanno J, Laufer H, Marcus M, Mclachlan JA, Nadal A, Oehlmann J, Olea N, Palanza P, Parmigiani S, Rubin BS, Schoenfelder G, Sonnenschein C, Soto AM, Taisness CE, Taylor JA, Vandenberg LN, Vandenbergh JG, Vogel S, Watson CS, Welshons WV, Zoeller RT. 2009.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Background:<\/strong> In their safety evaluations of bisphenol A (BPA), the U.S. Food and Drug Administration (FDA) and a counterpart in Europe, the European Food Safety Authority (EFSA), have given special prominence to two industry-funded studies that adhered to standards defined by Good Laboratory Practices (GLP). These same agencies have given much less weight in risk assessments to a large number of independently replicated non-GLP studies conducted with government funding by the leading experts in various fields of science from around the world.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Objectives:<\/strong> We reviewed differences between industry-funded GLP studies of BPA conducted by commercial laboratories for regulatory purposes and non-GLP studies conducted in academic and government laboratories to identify hazards and molecular mechanisms mediating adverse effects. We examined the methods and results in the GLP studies that were pivotal in the draft decision of the U.S. FDA declaring BPA safe in relation to findings from studies that were competitive for U.S. National Institutes of Health (NIH) funding, peer-reviewed for publication in leading journals, subject to independent replication, but rejected by the U.S. FDA for regulatory purposes.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Discussion:\u00a0<\/strong>Although the U.S. FDA and EFSA have deemed two industry-funded GLP studies of BPA to be superior to hundreds of studies funded by the U.S. NIH and NIH counterparts in other countries, the GLP studies on which the agencies based their decisions have serious conceptual and methodologic flaws. In addition, the U.S. FDA and EFSA have mistakenly assumed that GLP yields valid and reliable scientific findings (i.e., \u201cgood science\u201d). Their rationale for favoring GLP studies over hundreds of publically funded studies ignores the central factor in determining the reliability and validity of scientific findings, namely, independent replication, and use of the most appropriate and sensitive state-of-the-art assays, neither of which is an expectation of industry-funded GLP research.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong>Conclusions:\u00a0<\/strong>Public health decisions should be based on studies using appropriate protocols with appropriate controls and the most sensitive assays, not GLP. Relevant NIH-funded research using state-of-the-art techniques should play a prominent role in safety evaluations of chemicals.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"https:\/\/ehp.niehs.nih.gov\/0800173\/\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<div><\/div>\n<\/div>\n<div id=\"pub23\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Pesticides, Sexual Development, Reproduction, and Fertility: Current Perspective and Future Direction<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Colborn T, Carroll LE. 2007.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Improvements in chemical analytical technology and non-invasive sampling protocols have made it easier to detect pesticides and their metabolites at very low concentrations in human tissues. Monitoring has revealed that pesticides penetrate both maternal and paternal reproductive tissues and organs, thus providing a pathway for initiating harm to their offspring starting before fertilization throughout gestation and lactation. This article explores the literature that addresses the parental pathway of exposure to pesticides. We use DDT\/DDE as a model for chemicals that oftentimes upon exposure have no apparent, immediate health impacts, or cause no obvious birth defects, and are seldom linked with cancer. Their health effects are overlooked because they are invisible and not life threatening\u2014but might have significant health, social, and economic impacts at the individual and population levels. The purpose of this article is to demonstrate the necessity to develop new approaches for determining the safety of pesticides and the need for innovative regulatory policy to protect human and environmental health.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"http:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/10807030701506405\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<div><\/div>\n<\/div>\n<div id=\"pub24\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">A Case for Revisiting the Safety of Pesticides: A Closer Look at Neurodevelopment<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Colborn T. 2006.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">The quality and quantity of the data about the risk posed to humans by individual pesticides vary considerably. Unlike obvious birth defects, most developmental effects cannot be seen at birth or even later in life. Instead, brain and nervous system disturbances are expressed in terms of how an individual behaves and functions, which can vary considerably from birth through adulthood. In this article I challenge the protective value of current pesticide risk assessment strategies in light of the vast numbers of pesticides on the market and the vast number of possible target tissues and end points that often differ depending upon timing of exposure. Using the insecticide chlorpyrifos as a model, I reinforce the need for a new approach to determine the safety of all pesticide classes. Because of the uncertainty that will continue to exist about the safety of pesticides, it is apparent that a new regulatory approach to protect human health is needed.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1332649\/\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<div><\/div>\n<\/div>\n<div id=\"pub25\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Endocrine Disruption Overview: Are Males at Risk?<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Colborn T. 2004.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">The goal of this paper is to encourage physicians and others responsible for public health to start thinking outside of the box \u2014 to consider what has been learned from wildlife that has contributed considerably toward understanding the etiology of a number of human disorders that have increased significantly over the past 50 years in the developed world. Hopefully this will lead to practitioners\u2019 thinking in broader terms when the etiology of a disorder is not evident. The increased incidence of hypospadias, for instance, would not have been discovered if it had not been for a troubled population of alligators in Lake Apopka, Florida. The reproductive success of the alligators had dropped to 10% and many of the males had undersized phalluses. These findings led to a series of laboratory studies that eventually revealed that there are synthetic anti-androgens in the environment that can interfere with male development and function. Serendipitous discoveries such as this concerning wildlife health have led to intense scrutiny concerning the etiology of a number of other human disorders related to the endocrine system such as abnormal sexual development and neurological and reproductive impairment.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"http:\/\/link.springer.com\/chapter\/10.1007%2F978-1-4419-8995-6_12\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<div><\/div>\n<\/div>\n<div id=\"pub26\" class=\"pub-container\">\n<p class=\"pub-title\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Neurodevelopment and Endocrine Disruption<\/span><\/em><\/p>\n<p class=\"pub-citation\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Colborn T. 2004.<\/span><\/p>\n<div class=\"pub-abstract\">\n<h4><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">ABSTRACT<\/span><\/h4>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">In this article I explore the possibility that contaminants contribute to the increasing prevalence of attention deficit hyperactivity disorder, autism, and associated neurodevelopmental and behavioral problems in developed countries. I discuss the exquisite sensitivity of the embryo and fetus to thyroid disturbance and provide evidence of human in utero exposure to contaminants that can interfere with the thyroid. Because it may never be possible to link prenatal exposure to a specific chemical with neurodevelopmental damage in humans, I also present alternate models where associations have been made between exposure to specific chemicals or chemical classes and developmental difficulties in laboratory animals, wildlife, and humans.<\/span><\/p>\n<\/div>\n<div class=\"pub-buttons\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><a class=\"pub-toggle showit\">ABSTRACT<\/a> | <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1247186\/\" target=\"_blank\" rel=\"noopener noreferrer\">FULL TEXT<\/a><\/span><\/div>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In much the same way we had to push GE and the EPA and the Massachusetts agencies to fully recognize the extent of the PCB contamination, we had to pressure them to acknowledge the significant numbers of GE employees, and local residents who were suffering adverse health effects from their exposure to PCBs. We began [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":{"nf_dc_page":"","om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"class_list":["post-445","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/cleanthehousatonic.com\/index.php?rest_route=\/wp\/v2\/pages\/445","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cleanthehousatonic.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cleanthehousatonic.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cleanthehousatonic.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cleanthehousatonic.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=445"}],"version-history":[{"count":5,"href":"https:\/\/cleanthehousatonic.com\/index.php?rest_route=\/wp\/v2\/pages\/445\/revisions"}],"predecessor-version":[{"id":677,"href":"https:\/\/cleanthehousatonic.com\/index.php?rest_route=\/wp\/v2\/pages\/445\/revisions\/677"}],"wp:attachment":[{"href":"https:\/\/cleanthehousatonic.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=445"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}